Abstract | BACKGROUND: OBJECTIVES: SEARCH METHODS: We searched the literature in January 2012, using the search strategy recommended by the Cochrane Neonatal Group. We searched electronic databases (CENTRAL (The Cochrane Library), MEDLINE, CINAHL, EMBASE), abstracts of the Pediatric Academic Societies, web sites for registered trials at www.clinicaltrials.gov and www.controlled-trials.com and in the reference list of identified articles. SELECTION CRITERIA: Randomized or quasi-randomized trials evaluating vasopressin or its analogues, at any dosage or duration used as an adjunct to standard therapy (any combination of volume expansion, inotropic agents and corticosteroids) to treat refractory hypotension in neonates. DATA COLLECTION AND ANALYSIS: We followed the standard methods of The Cochrane Collaboration for conducting a systematic review. Two review authors (BS and MP) independently assessed the titles and abstracts of studies identified by the search strategy for eligibility for inclusion. We obtained the full text version if eligibility could not be done reliably by title and abstract. We resolved any differences by mutual discussion. We designed electronic forms for trial inclusion/exclusion, data extraction, and for requesting additional published information from authors of the original reports. MAIN RESULTS: Our search did not identify any completed or ongoing trials that met our inclusion criteria. Three studies that did not include neonates and one study where the objective was not to treat neonates with refractory hypotension were excluded. AUTHORS' CONCLUSIONS: There is insufficient evidence to recommend or refute the use of vasopressin or its analogues in the treatment of refractory hypotension in neonates. Well-designed, adequately powered, randomized controlled studies are necessary to address efficacy, optimal dosing, safety and long-term neurodevelopmental and pulmonary outcomes.
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Authors | Binoy Shivanna, Danielle Rios, Joseph Rossano, Caraciolo J Fernandes, Mohan Pammi |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 3
Pg. CD009171
(Mar 28 2013)
ISSN: 1469-493X [Electronic] England |
PMID | 23543571
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review, Systematic Review)
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Chemical References |
- Vasoconstrictor Agents
- Vasopressins
- Lypressin
- Terlipressin
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Topics |
- Humans
- Hypotension
(drug therapy)
- Infant, Newborn
- Lypressin
(analogs & derivatives, therapeutic use)
- Terlipressin
- Vasoconstrictor Agents
(therapeutic use)
- Vasopressins
(therapeutic use)
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