Abstract | BACKGROUND: OBJECTIVE: We sought to investigate associations between confirmed DLE and other SLE manifestations, adjusting for confounders. METHODS: We identified patients with rheumatologist confirmation, according to 1997 American College of Rheumatology (ACR) SLE classification criteria, more than 2 visits, longer than 3 months of follow-up, and documented year of SLE diagnosis. DLE was confirmed by a dermatologist, supported by histopathology and images. SLE manifestations, medications, and serologies were collected. Multivariable-adjusted logistic regression analyses tested for associations between DLE and each of the ACR SLE criteria, and ESRD. RESULTS: A total of 1043 patients with SLE (117 with DLE and 926 without DLE) were included in the study. After multivariable adjustment, DLE in SLE was significantly associated with photosensitivity (odds ratio [OR] 1.63), leukopenia (OR 1.55), and anti-Smith antibodies (OR 2.41). DLE was significantly associated with reduced risks of arthritis (OR 0.49) and pleuritis (OR 0.56). We found no significant associations between DLE and nephritis or ESRD. LIMITATIONS: Cross-sectional data collection with risk of data not captured from visits outside system was a limitation. CONCLUSIONS:
|
Authors | Joseph F Merola, Stephen D Prystowsky, Christina Iversen, Jose A Gomez-Puerta, Tabatha Norton, Peter Tsao, Elena Massarotti, Peter Schur, Bonnie Bermas, Karen H Costenbader |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 69
Issue 1
Pg. 19-24
(Jul 2013)
ISSN: 1097-6787 [Electronic] United States |
PMID | 23541758
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Copyright | Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved. |
Topics |
- Adult
- Comorbidity
- Cross-Sectional Studies
- Female
- Humans
- Logistic Models
- Lupus Erythematosus, Discoid
(epidemiology)
- Lupus Erythematosus, Systemic
(epidemiology)
- Male
- Prognosis
- Young Adult
|