Abstract | BACKGROUND: OBJECTIVE: METHODS: Adult male Wistar rats were randomly divided into 5 groups: the Sham group, the I/R group, the Dzx + I/R group, the Dzx + Sper + I/R group, and the Sper + I/R group. Rats were exposed to 2-hour ischemia and 24-hour reperfusion. Diazoxide were administrated 30 minutes before ischemia, and spermine were given 10 minutes before reperfusion. Rats in the Sham group did not experience the process of ischemia-reperfusion. After 24-hour reperfusion, rats were given neurological performance tests, overdosed with general anesthesia, and then their brains were excised for infarct volume, pathological changes, and biochemical evaluation and analysis. RESULTS: CONCLUSIONS:
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Authors | Huanli Dong, Shilei Wang, Zongwang Zhang, Ailan Yu, Zhong Liu |
Journal | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
(J Stroke Cerebrovasc Dis)
Vol. 23
Issue 2
Pg. 303-9
(Feb 2014)
ISSN: 1532-8511 [Electronic] United States |
PMID | 23540254
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Calcium Channels
- Neuroprotective Agents
- Potassium Channels
- mitochondrial K(ATP) channel
- mitochondrial calcium uniporter
- Spermine
- Nitric Oxide
- Malondialdehyde
- Glutathione Peroxidase
- Superoxide Dismutase
- Diazoxide
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Topics |
- Animals
- Behavior, Animal
(drug effects)
- Brain
(drug effects, metabolism, pathology, physiopathology)
- Calcium Channels
(drug effects, metabolism)
- Cerebral Infarction
(diagnosis, metabolism, pathology, physiopathology, prevention & control)
- Cytoprotection
- Diazoxide
(pharmacology)
- Disease Models, Animal
- Glutathione Peroxidase
(metabolism)
- Male
- Malondialdehyde
(metabolism)
- Mitochondria
(drug effects, metabolism)
- Motor Activity
(drug effects)
- Neuroprotective Agents
(pharmacology)
- Nitric Oxide
(metabolism)
- Oxidative Stress
(drug effects)
- Potassium Channels
(drug effects, metabolism)
- Rats
- Rats, Wistar
- Reperfusion Injury
(diagnosis, metabolism, pathology, physiopathology, prevention & control)
- Spermine
(toxicity)
- Superoxide Dismutase
(metabolism)
- Time Factors
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