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Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice.

Abstract
Chaga mushrooms (Inonotus obliquus) are hypothesised to exhibit general immune-potentiating, anti-inflammatory, and antitumor properties, but their anti-allergic activities are not fully understood. Therefore, this study investigated whether a chaga mushroom extract (C-HE) might have anti-allergic activity. This activity was assessed through the levels of the IgE Ab produced in response to an allergen (OVA). The administration of C-HE prophylactically inhibited the systemic anaphylactic shock induced by compound 48/80 in mice. The oral administration of C-HE significantly reduced the total IgE levels in mice and slightly affected the production of IgG1. Furthermore, spleen cell cultures harvested from OVA-sensitised mice that had received C-HE orally showed a significant increase in Th1-derived responses (IFN-γ production). Therefore, our results suggest that the chaga mushroom extract may be used as an anti-allergic functional food.
AuthorsTaek Joon Yoon, Sue Jung Lee, Eun Young Kim, Eun Hee Cho, Tae Bong Kang, Kwang-Won Yu, Hyung Joo Suh
JournalInternational immunopharmacology (Int Immunopharmacol) Vol. 15 Issue 4 Pg. 666-70 (Apr 2013) ISSN: 1878-1705 [Electronic] Netherlands
PMID23535020 (Publication Type: Journal Article)
CopyrightCopyright © 2013. Published by Elsevier B.V.
Chemical References
  • Anti-Allergic Agents
  • Immunoglobulin E
  • p-Methoxy-N-methylphenethylamine
  • Interferon-gamma
  • Ovalbumin
Topics
  • Anaphylaxis (chemically induced, immunology, prevention & control)
  • Animals
  • Anti-Allergic Agents (isolation & purification, therapeutic use)
  • Basidiomycota (chemistry)
  • Cells, Cultured
  • Female
  • Immunoglobulin E (blood, immunology)
  • Interferon-gamma (biosynthesis, immunology)
  • Mice
  • Mice, Inbred BALB C
  • Ovalbumin (immunology)
  • Spleen (cytology, drug effects, immunology)
  • Th1 Cells (drug effects, immunology)
  • p-Methoxy-N-methylphenethylamine (immunology, toxicity)

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