Abstract |
Chaga mushrooms (Inonotus obliquus) are hypothesised to exhibit general immune-potentiating, anti-inflammatory, and antitumor properties, but their anti-allergic activities are not fully understood. Therefore, this study investigated whether a chaga mushroom extract (C-HE) might have anti-allergic activity. This activity was assessed through the levels of the IgE Ab produced in response to an allergen (OVA). The administration of C-HE prophylactically inhibited the systemic anaphylactic shock induced by compound 48/80 in mice. The oral administration of C-HE significantly reduced the total IgE levels in mice and slightly affected the production of IgG1. Furthermore, spleen cell cultures harvested from OVA-sensitised mice that had received C-HE orally showed a significant increase in Th1-derived responses (IFN-γ production). Therefore, our results suggest that the chaga mushroom extract may be used as an anti-allergic functional food.
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Authors | Taek Joon Yoon, Sue Jung Lee, Eun Young Kim, Eun Hee Cho, Tae Bong Kang, Kwang-Won Yu, Hyung Joo Suh |
Journal | International immunopharmacology
(Int Immunopharmacol)
Vol. 15
Issue 4
Pg. 666-70
(Apr 2013)
ISSN: 1878-1705 [Electronic] Netherlands |
PMID | 23535020
(Publication Type: Journal Article)
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Copyright | Copyright © 2013. Published by Elsevier B.V. |
Chemical References |
- Anti-Allergic Agents
- Immunoglobulin E
- p-Methoxy-N-methylphenethylamine
- Interferon-gamma
- Ovalbumin
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Topics |
- Anaphylaxis
(chemically induced, immunology, prevention & control)
- Animals
- Anti-Allergic Agents
(isolation & purification, therapeutic use)
- Basidiomycota
(chemistry)
- Cells, Cultured
- Female
- Immunoglobulin E
(blood, immunology)
- Interferon-gamma
(biosynthesis, immunology)
- Mice
- Mice, Inbred BALB C
- Ovalbumin
(immunology)
- Spleen
(cytology, drug effects, immunology)
- Th1 Cells
(drug effects, immunology)
- p-Methoxy-N-methylphenethylamine
(immunology, toxicity)
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