Novel risk factors for premature peripheral arterial occlusive disease in non-diabetic patients: a case-control study.
Abstract | BACKGROUND: METHODS AND RESULTS: This study included 113 non diabetic patients with premature peripheral arterial disease (diagnosis <45-year old) presenting either a peripheral arterial occlusive disease (Nā=ā64) or a thromboangiitis obliterans (Nā=ā49), and 241 controls matched for age and gender. Both patient groups demonstrated common traits including cigarette smoking, low physical activity, decreased levels of HDL-cholesterol, apolipoprotein A-I, pyridoxal 5'-phosphate (active form of B6 vitamin) and zinc. Premature peripheral arterial occlusive disease was characterized by the presence of a family history of peripheral arterial and carotid artery diseases (OR 2.3 and 5.8 respectively, 95% CI), high lipoprotein (a) levels above 300 mg/L (OR 2.3, 95% CI), the presence of the factor V Leiden (OR 5.1, 95% CI) and the glycoprotein Ia(807T,837T,873A) allele (OR 2.3, 95% CI). In thromboangiitis obliterans group, more patients were regular consumers of cannabis (OR 3.5, 95% CI) and higher levels in plasma copper has been shown (OR 6.5, 95% CI). CONCLUSIONS:
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Authors | Annie M Bérard, Aurélie Bedel, Rémi Le Trequesser, Geneviève Freyburger, Alan Nurden, Sylvie Colomer, Viviane Guérin, Marie-Christine Vergnes, François Becker, Gabriel Camelot, Luc Bressolette, Philippe Lacroix, Jean-Pierre Cambou, Alessandra Bura-Rivière, Joseph Emmerich, Michel Darmon, Anne-Marie Deletraz, Samir Mesli, Brigitte Colombies, Virginie Vanbrugghe, Claude Conri, Joël Constans |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 3
Pg. e37882
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23533563
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Histocompatibility Antigens Class II
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Topics |
- Adolescent
- Adult
- Age Factors
- Case-Control Studies
- Female
- Histocompatibility Antigens Class II
(genetics)
- Humans
- Male
- Middle Aged
- Peripheral Arterial Disease
(epidemiology, genetics)
- Polymorphism, Genetic
(genetics)
- Risk Factors
- Smoking
(adverse effects)
- Thromboangiitis Obliterans
(epidemiology, genetics)
- Young Adult
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