Serum hemorphin-7 levels are decreased in obesity.

Abstract

OBJECTIVE:

Hemorphin peptides exhibit biological activities that interfere with the endorphin system, the inflammatory response, and blood-pressure control. VV-hemorphin-7 and LVV-hemorphin-7 peptides exert a hypotensive effect, in particular, by inhibiting the renin-angiotensin system. Furthermore, levels of circulating hemorphin-7 peptides have been found to be decreased in diseases such as type 1 and type 2 diabetes.

DESIGN AND METHODS:

Because type 2 diabetes and obesity share common features, such as insulin resistance, microinflammation, high glomerular-filtration rate (GFR), and cardiovascular risk, we evaluated serum VV-hemorphin-7 like immunoreactivity (VVH7-i.r.) levels, using an enzyme-linked immunosorbent assay method, on a group of 54 obese subjects without diabetes or hypertension, compared with a group of 33 healthy normal-weight subjects.

RESULTS:

Circulating VVH7-i.r. levels were significantly decreased in the obese group compared with the control group (1.98 ± 0.19 vs. 4.86 ± 0.54 µmol/l, respectively, P < 0.01), and a significant negative correlation between VVH7-i.r. and diastolic blood pressure (DBP) was found in obese patients (r = -0.35, P = 0.011). There was no significant correlation between VVH7-i.r. level and insulin resistance, metabolic syndrome, or GFR.

CONCLUSIONS:

The decreased serum hemorphin-7 found in obese subjects, as in diabetes, may contribute to the development of hypertension and to the cardiovascular risk associated with these metabolic diseases.

• Authors: Marie Maraninchi, Delphine Feron, Ingrid Fruitier-Arnaudin, Audrey Bégu-Le Corroller, Juan P Nogueira, Julien Mancini, René Valéro, Jean M Piot, Bernard Vialettes
• Journal: Obesity (Silver Spring, Md.) (Obesity (Silver Spring)) Vol. 21 Issue 2 Pg. 378-81 (Feb 2013) ISSN: 1930-739X [Electronic] United States
• PMID: 23532992 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 The Obesity Society.

Chemical References

• Hemoglobins
• Insulin
• Peptide Fragments
• hemorphin 7
• LVV-hemorphin-7
• VV-hemorphin-7

Topics

• Adult
• Blood Pressure
• Body Mass Index
• Case-Control Studies
• Diabetes Mellitus, Type 2 (blood, complications)
• Enzyme-Linked Immunosorbent Assay
• Female
• Glomerular Filtration Rate
• Hemoglobins
• Humans
• Hypertension (blood, complications)
• Insulin (blood)
• Insulin Resistance
• Male
• Metabolic Syndrome (blood, complications)
• Middle Aged
• Obesity (blood, complications)
• Peptide Fragments (blood)
• Renin-Angiotensin System
• Risk Factors