Twelve cases of
thymomas with prominent glandular differentiation are presented. The patients were 7 men and 5 women aged between 45 and 68 years (average, 56.5 years). Clinically, the patients presented with nonspecific symptoms of
chest pain,
cough, and
fatigue. None of the patients had a history of
myasthenia gravis or other autoimmune syndrome.
Thymectomy was performed in all patients. The
tumor size ranged from 4 to 7 cm in greatest diameter. Macroscopically, the
tumors were described as firm and light tan without areas of
necrosis,
hemorrhage, or cystic change. Histologically, 7
tumors were classified as spindle cell (World Health Organization type A), 2 as mixed spindle cell and conventional (A+B1), 2 as conventional (B1), and 1 as atypical
thymoma (B3). In 4 cases, the
tumors showed invasion into periadipose thymic tissue. All cases showed the typical growth patterns of their particular subtypes. In addition, a distinct glandular component was present in all cases showing mucinous differentiation in 4 of them. Immunohistochemical studies showed
tumor cells positive for
CAM5.2,
cytokeratin 5/6, and Pax8 and negative for
carcinoembryonic antigen,
thyroid transcription factor 1, and
epithelial membrane antigen.
Calretinin showed focal weak staining in the nonmucinous glandular components in 3 cases. Follow-up information obtained in 8 patients showed that all were alive and well in a period ranging from 2 to 5 years. The possibility of a glandular component in
thymomas should be kept in mind in the assessment of mediastinoscopic biopsies to avoid misdiagnosis for other
neoplasms that may require different treatment modalities.