Abstract | BACKGROUND: Kidneys from pediatric donors weighing <10 kg are preferably transplanted en bloc, while kidneys from donors weighing >15 kg can be safely transplanted as single kidneys. However, single kidney transplantation from donors weighing 10-14 kg is controversial and has not been well investigated. METHODS: We analyzed the outcome of 15 recipients of single kidneys from donors weighing 10-14 kg (study group) with 40 recipients receiving an allograft from ideal deceased donors (control group). RESULTS: After a follow-up of three yr, death-censored graft survival was 100% in both groups. The calculated creatinine clearance was lower in the study group at six months (53 vs. 71 mL/min; p = 0.01) and similar at 12 months (68 vs. 68 mL/min; p = 0.48), 24 months (81 vs. 70 mL/min; p = 0.58), and 36 months (74 vs. 69 mL/min; p = 0.59). Urinary albumin/ creatinine ratios were comparable between the two groups up to two yr. At three yr, urinary albumin/ creatinine ratios were higher in the study group than the control group (10.5 vs. 0.9 mg/mmol; p = 0.007). Surveillance biopsies at three and six months post-transplant revealed no evidence for focal segmental glomerulosclerosis in the study group. CONCLUSIONS:
Transplantation of single pediatric kidneys from donors weighing 10-14 kg into adult recipients provides excellent intermediate-term outcomes. Low-grade albuminuria, three yr post-transplant, might indicate late-onset hyperfiltration injury.
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Authors | Isabel Gröschl, Thomas Wolff, Lorenz Gürke, Thomas Eugster, Helmut Hopfer, Jürg Steiger, Stefan Schaub, Felix Burkhalter |
Journal | Clinical transplantation
(Clin Transplant)
2013 May-Jun
Vol. 27
Issue 3
Pg. E302-7
ISSN: 1399-0012 [Electronic] Denmark |
PMID | 23528134
(Publication Type: Comparative Study, Journal Article)
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Copyright | © 2013 John Wiley & Sons A/S. |
Topics |
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Child, Preschool
- Female
- Follow-Up Studies
- Glomerular Filtration Rate
- Glomerulosclerosis, Focal Segmental
(diagnosis, etiology)
- Humans
- Infant
- Kidney Diseases
(complications, mortality, surgery)
- Kidney Transplantation
- Male
- Middle Aged
- Postoperative Complications
- Prognosis
- Retrospective Studies
- Risk Factors
- Survival Rate
- Young Adult
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