Abstract | OBJECTIVE: METHODS: A masked, randomized clinical trial for one dose of 1 ml of oral 25% glucose solution 2 minutes before the first ophthalmologic examination for retinopathy of prematurity was conducted between March 2008 and April 2010. The results were compared to those of a control group that did not receive oral glucose solution. Pain was evaluated using a Neonatal Infant Pain Scale immediately before and immediately after the ophthalmologic examination in both groups. Clinicaltrials.gov: NCT00648687 RESULTS: One hundred and twenty-four patients who were examined for the first time for retinopathy of prematurity were included. Seventy were included in the intervention group and 54 in the control group. The number of patients with pain immediately before the procedure was similar in both groups. The number of patients with pain after ophthalmologic examination was 15.7% in the intervention group and 68.5% in the control group (p<0.001). CONCLUSIONS:
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Authors | Marlene Coelho da Costa, Gabriela Unchalo Eckert, Barbara Gastal Borges Fortes, João Borges Fortes Filho, Rita C Silveira, Renato S Procianoy |
Journal | Clinics (Sao Paulo, Brazil)
(Clinics (Sao Paulo))
Vol. 68
Issue 2
Pg. 199-204
( 2013)
ISSN: 1980-5322 [Electronic] United States |
PMID | 23525316
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Administration, Oral
- Analgesics
(administration & dosage, pharmacology)
- Analysis of Variance
- Eye
(drug effects)
- Eye Pain
(prevention & control)
- Female
- Glucose
(administration & dosage, pharmacology)
- Humans
- Infant, Newborn
- Pain Measurement
- Retinopathy of Prematurity
(diagnosis)
- Time Factors
- Treatment Outcome
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