Abstract | INTRODUCTION: Chronic dental periapical lesions result from chronic inflammation of periapical tissues caused by continuous antigenic stimulation from infected root canals. Recent findings have suggested that T helper (Th) 1 and Th2-like cytokines are important in the pathogenesis of chronic periapical inflammatory diseases. However, the mechanisms regulating these immunoinflammatory pathways have not been fully elucidated. Thus, the aim of this study was to evaluate interleukin (IL)-4, IL-12, and interferon γ (IFN-γ) protein levels in human radicular cysts and periapical granulomas. METHODS: Archived samples of cysts (n = 52) and granulomas (n = 27) were sectioned and submitted to immunohistochemistry to evaluate the tissue expression of IL-4, IL-12, and IFN-γ. The data were analyzed using the Mann-Whitney U test (P < .05). RESULTS: CONCLUSIONS:
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Authors | Carlos Alberto de Carvalho Fraga, Lucas Rodrigues Alves, Adriana Alkmim de Sousa, Sabrina Ferreira de Jesus, Daniel Nogueira Vilela, Camila Santos Pereira, Patrícia Luciana Batista Domingos, Agostinho Gonçalves Viana, Bruno Correia Jham, Alfredo Maurício Batista de Paula, André Luiz Sena Guimarães |
Journal | Journal of endodontics
(J Endod)
Vol. 39
Issue 4
Pg. 453-5
(Apr 2013)
ISSN: 1878-3554 [Electronic] United States |
PMID | 23522535
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 American Association of Endodontists. All rights reserved. |
Chemical References |
- Interleukin-12
- Interleukin-4
- Interferon-gamma
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Topics |
- Adult
- Cross-Sectional Studies
- Female
- Humans
- Interferon-gamma
(metabolism)
- Interleukin-12
(metabolism)
- Interleukin-4
(metabolism)
- Male
- Middle Aged
- Periapical Granuloma
(immunology)
- Radicular Cyst
(immunology)
- Statistics, Nonparametric
- Th1-Th2 Balance
- Young Adult
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