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Synthesis and biological activity of a series of aspartate transcarbamoylase inhibitors: N-substituted diethyl aspartates and N-substituted-3-oxo-1,4-piperazine-2-acetic acid esters.

Abstract
Series of N-substituted diethyl aspartates and N-substituted-3-oxo-1,4-piperazine-2-acetic acid esters were synthesized as potential inhibitors of aspartate transcarbamoylase. The aspartates were obtained by addition of substituted alkyl amines to diethyl maleate, or conversion of the hydroxy ethyl amino adduct to other functions. The 3-oxo-1,4-piperazine-2-acetic acid esters were prepared by addition of ethylene diamine to diethyl maleate, followed by cyclization. Addition of 1,2-diamino-2-methylpropane gave the corresponding 5,5-dimethyl-3-oxo-1,4-piperazine-2-acetic acid ester. N-Acyl derivatives in each series were obtained using the bromoacyl chlorides. A majority of the compounds in each series showed antimicrobial activity against five representative microorganisms, as well as significant activity against aspartate transcarbamoylase. Four of the compounds were found to have significant specificity against several tumor cell lines. A distance of two carbons between N and a reactive function was found to give the best activity for either antimicrobial, antienzyme, or tumor cell specificity activities, in either the open chain aspartates or cyclic piperazines. Little difference in anti-enzyme activity was found between the aspartates and piperazines, but introduction of the planar phenyl substituents lowered inhibitory activity.
AuthorsP L Dutta, W O Foye
JournalJournal of pharmaceutical sciences (J Pharm Sci) Vol. 79 Issue 5 Pg. 447-52 (May 1990) ISSN: 0022-3549 [Print] United States
PMID2352167 (Publication Type: Journal Article)
Chemical References
  • Aspartic Acid
  • sparfosic acid
  • Aspartate Carbamoyltransferase
  • Phosphonoacetic Acid
Topics
  • Aspartate Carbamoyltransferase (antagonists & inhibitors)
  • Aspartic Acid (analogs & derivatives, pharmacology)
  • Chemical Phenomena
  • Chemistry, Physical
  • Drug Screening Assays, Antitumor
  • Microbial Sensitivity Tests
  • Phosphonoacetic Acid (analogs & derivatives, pharmacology)

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