The association between the poly(A) polymorphism in the VDR gene and cancer risk: a meta-analysis.

Abstract

The poly(A) polymorphism (L/S) in the VDR gene has been implicated in susceptibility of cancer, but a number of studies have reported inconclusive results. The aim of this study is to investigate the relationship between the poly(A) polymorphism in the VDR gene and cancer risk by meta-analysis. We searched PubMed database, EMBASE database, CNKI database, and Wanfang database, covering all studies until January 22, 2013. Statistical analysis was performed by using the software Revman4.2 and STATA 10.0. A total 8,186 cancer cases and 8,685 controls in 19 case-control studies from 15 studies were identified for data analysis. The results suggested that the S allele carriers (SS+SL) did not have an increased or decreased risk of cancer when compared with the homozygote LL carriers (odds ratio (OR) =0.96, 95 % CI=0.87-1.06, P=0.43 for SS+SL vs. LL). In addition, in the subgroup analysis by ethnicity and cancer type, no significant association was found among Caucasians, African-Americans, prostate cancer, or breast cancer. This current meta-analysis suggested that the poly(A) polymorphism in the VDR gene may not contribute to the risk of cancer. Future studies are needed to validate our findings.

• Authors: Jin Huang, Jiqiao Yang, Haichuan Wang, Tianyuan Xiong, Hongbo Zhang, Yaxian Ma, Xiaoze Wang, Jichong Huang, Liang Du
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 34 Issue 3 Pg. 1833-8 (Jun 2013) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 23519839 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Calcitriol
• VDR protein, human

Topics

• Case-Control Studies
• Genetic Predisposition to Disease
• Humans
• Neoplasms (etiology)
• Polymorphism, Genetic (genetics)
• Receptors, Calcitriol (genetics)
• Risk Factors