Relationship between the clinical global impression of severity for schizoaffective disorder scale and established mood scales for mania and depression.

Abstract

BACKGROUND:

This analysis explored the relationship between ratings on HAM-D-17 or YMRS and those on the depressive or manic subscale of CGI-S for schizoaffective disorder (CGI-S-SCA).

METHODS:

This post hoc analysis used the database (N=614) from two 6-week, randomized, placebo-controlled studies of paliperidone ER versus placebo in symptomatic subjects with schizoaffective disorder assessed using HAM-D-17, YMRS, and CGI-S-SCA scales. Parametric and nonparametric regression models explored the relationships between ratings on YMRS and HAM-D-17 and on depressive and manic domains of the CGI-S-SCA from baseline to the 6-week end point. A clinically meaningful improvement was defined as a change of 1 point in the CGI-S-SCA score. No adjustment was made for multiplicity.

RESULTS:

Multiple linear regression models suggested that a 1-point change in the depressive domain of CGI-S-SCA corresponded to an average 3.6-point (SE=0.2) change in HAM-D-17 score. Similarly, a 1-point change in the manic domain of CGI-S-SCA corresponded to an average 5.8-point (SE=0.2) change in YMRS score. Results were confirmed using local and cumulative logistic regression models in addition to equipercentile linking.

LIMITATIONS:

Lack of subjects scoring over the complete range of possible scores may limit broad application of the analyses.

CONCLUSION:

Clinically meaningful score changes in depressive and manic domains of CGI-S-SCA corresponded to approximately 4- and 6-point score changes on HAM-D-17 and YMRS, respectively, in symptomatic subjects with schizoaffective disorder.

• Authors: Ibrahim Turkoz, Dong-Jing Fu, Cynthia A Bossie, John J Sheehan, Larry Alphs
• Journal: Journal of affective disorders (J Affect Disord) Vol. 150 Issue 1 Pg. 17-22 (Aug 15 2013) ISSN: 1573-2517 [Electronic] Netherlands
• PMID: 23517884 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Antipsychotic Agents
• Isoxazoles
• Pyrimidines
• Paliperidone Palmitate

Topics

• Adult
• Antipsychotic Agents (therapeutic use)
• Bipolar Disorder (diagnosis)
• Depression (diagnosis)
• Female
• Humans
• Isoxazoles (therapeutic use)
• Male
• Paliperidone Palmitate
• Psychiatric Status Rating Scales
• Psychotic Disorders (diagnosis, drug therapy)
• Pyrimidines (therapeutic use)
• Severity of Illness Index