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Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer.

Abstract
Colorectal Cancer (CRC) is the second leading cause of cancer-related mortality and is the fourth most common malignant neoplasm in USA. Escaping apoptosis and cell mutation are the prime hallmarks of cancer. It is apparent that balancing the network between DNA damage and DNA repair is critical in preventing carcinogenesis. One-third of cancers might be prevented by nutritious healthy diet, maintaining healthy weight and physical activity. In this review, an attempt is made to abridge the role of carcinogen in colorectal cancer establishment and prognosis, where special attention has been paid to food-borne mutagens and functional role of beneficial human gut microbiome in evading cancer. Further the significance of tailor-made prebiotics, probiotics and synbiotics in cancer management by bio-antimutagenic and desmutagenic activity has been elaborated. Probiotic bacteria are live microorganisms that, when administered in adequate amounts, confer a healthy benefit on the host. Prebiotics are a selectively fermentable non-digestible oligosaccharide or ingredient that brings specific changes, both in the composition and/or activity of the gastrointestinal microflora, conferring health benefits. Synbiotics are a combination of probiotic bacteria and the growth promoting prebiotic ingredients that purport "synergism."
AuthorsMaya Raman, Padma Ambalam, Kanthi Kiran Kondepudi, Sheetal Pithva, Charmy Kothari, Arti T Patel, Ravi Kiran Purama, J M Dave, B R M Vyas
JournalGut microbes (Gut Microbes) 2013 May-Jun Vol. 4 Issue 3 Pg. 181-92 ISSN: 1949-0984 [Electronic] United States
PMID23511582 (Publication Type: Journal Article, Review)
Chemical References
  • Antimutagenic Agents
  • Immunologic Factors
  • Prebiotics
Topics
  • Antimutagenic Agents (administration & dosage)
  • Colorectal Neoplasms (therapy)
  • Gastrointestinal Tract (microbiology)
  • Humans
  • Immunologic Factors (administration & dosage)
  • Metagenome
  • Prebiotics
  • Probiotics (administration & dosage)
  • Synbiotics
  • United States

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