Postexposure subunit vaccination against chronic enteric mycobacterial infection in a natural host.

Abstract

The control of chronic bacterial diseases with high prevalence in areas of endemicity would strongly benefit from availability of postexposure vaccines. The development of these vaccines against mycobacterial infections, such as (para)tuberculosis, is hampered by lack of experience in natural hosts. Paratuberculosis in cattle is both a mycobacterial disease of worldwide importance and a natural host model for mycobacterial infections in general. The present study showed beneficial effects of therapeutic heat shock protein 70 (Hsp70) vaccination in cattle with naturally acquired chronic infection with Mycobacterium avium subsp. paratuberculosis. Vaccination-induced protection was associated with antibody responses, rather than with induction of specific T helper 1 cells. Targeted therapeutic postexposure vaccination complementary to selective use of antibiotics could be an effective approach for control of chronic mycobacterial infections.

• Authors: Wiebren Santema, Victor Rutten, Ruud Segers, Jacqueline Poot, Selma Hensen, Hans Heesterbeek, Ad Koets
• Journal: Infection and immunity (Infect Immun) Vol. 81 Issue 6 Pg. 1990-5 (Jun 2013) ISSN: 1098-5522 [Electronic] United States
• PMID: 23509147 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Bacterial Vaccines
• HSP70 Heat-Shock Proteins
• Protein Subunits
• Vaccines, Subunit

Topics

• Animals
• Antibodies, Bacterial (blood)
• Bacterial Vaccines (administration & dosage, immunology)
• Cattle
• Cattle Diseases (prevention & control)
• Chronic Disease
• Female
• HSP70 Heat-Shock Proteins (immunology)
• Mycobacterium avium subsp. paratuberculosis (immunology)
• Paratuberculosis (blood, immunology, prevention & control)
• Post-Exposure Prophylaxis (methods)
• Protein Subunits
• Vaccines, Subunit (administration & dosage, immunology)