[Three patients with local recurrence of ER-positive breast cancer for whom anastrozole was clinically effective].

Abstract

We treated three postmenopausal female patients with unresectable local recurrence from breast cancer. All pathological diagnoses of the local recurrence lesions were ER-positive breast cancer. For treatment, we administered anastrozole to these three patients. One has been stable disease for 25 months after taking anastrozole. Another has also showed stable disease for 18 months, and the last patient has been a partial response. We performed a biopsy from a recurring lesion on these three patients, and made a diagnosis of ER-positive breast cancer. This strategy of unresectable local recurrence revealed that these three patients could have had a stable condition for a long duration by taking anastrozole.

• Authors: Hitoshi Inari, Masanori Hashimoto, Kayo Uesugi, Naoki Goto, Shinsuke Hatori, Hiroyasu Tanabe, Hiroyuki Iwasaki
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 40 Issue 3 Pg. 361-3 (Mar 2013) ISSN: 0385-0684 [Print] Japan
• PMID: 23507599 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Nitriles
• Receptors, Estrogen
• Triazoles
• Anastrozole

Topics

• Aged
• Aged, 80 and over
• Anastrozole
• Antineoplastic Agents, Hormonal (therapeutic use)
• Biopsy
• Breast Neoplasms (chemistry, drug therapy, pathology)
• Female
• Humans
• Middle Aged
• Neoplasm Recurrence, Local (chemistry, drug therapy, pathology)
• Nitriles (therapeutic use)
• Postmenopause
• Receptors, Estrogen (analysis)
• Triazoles (therapeutic use)