Abstract | INTRODUCTION: AREAS COVERED: Published animal and human studies that evaluated the pharmacodynamics, pharmacokinetics, clinical efficacy and safety of peginesatide were critically analyzed. EXPERT OPINION:
Peginesatide has a well-studied pharmacological and immunological profile, and latest published data favor the use of peginesatide in place of epoetin in dialysis patients. A more detailed evaluation of its safety profile particularly in trials with CKD patients not requiring dialysis is urgently needed, as peginesatide could be a perfect treatment solution for these patients. In addition, clinical long-term data and results from supplemental studies, e.g., with the PEGylated continuous erythropoietin receptor activator as comparator, should briefly follow. The fate of peginesatide on the highly competitive ESA market is currently not predictable and depends on safety and efficacy results of upcoming trials as well as finally on market and price policy.
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Authors | Holger Schmid |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 14
Issue 7
Pg. 937-48
(May 2013)
ISSN: 1744-7666 [Electronic] England |
PMID | 23506424
(Publication Type: Journal Article, Review)
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Chemical References |
- Hematinics
- Peptides
- peginesatide
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Topics |
- Anemia
(drug therapy, etiology)
- Animals
- Clinical Trials as Topic
- Hematinics
(adverse effects, pharmacology, therapeutic use)
- Humans
- Peptides
(adverse effects, pharmacology, therapeutic use)
- Renal Insufficiency, Chronic
(complications)
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