The objective of this study is to observe the effects of high dose of
anisodamine in the respiratory function of patients with
acute lung injury (ALI) induced by
trauma. Fifty cases of patients with complicated ALI after
trauma were randomly divided into the
anisodamine treatment group (n = 26) and the conventional treatment group (n = 24).
Intravenous injection of high dose of
anisodamine was administrated in the
anisodamine treatment group on the basis of conventional treatment.
Acute lung injury scores, oxygenation index, PaO2, respiratory mechanic index,
mechanical ventilation time, and the occurrence of adverse reactions in the two groups were observed.
Acute lung injury scores and respiratory parameters were all significantly improved in the two groups of patients after the treatment (P < 0.05); compared with the conventional treatment group, the improvements of respiratory function in the
anisodamine treatment group were more obvious (P < 0.05), the
mechanical ventilation time was shorter (P < 0.05), and there was no significant adverse reaction. In conclusion, high dose of
anisodamine contributed to improve the respiratory function of the patients with traumatic ALI.