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Effects of high dose of anisodamine on the respiratory function of patients with traumatic acute lung injury.

Abstract
The objective of this study is to observe the effects of high dose of anisodamine in the respiratory function of patients with acute lung injury (ALI) induced by trauma. Fifty cases of patients with complicated ALI after trauma were randomly divided into the anisodamine treatment group (n = 26) and the conventional treatment group (n = 24). Intravenous injection of high dose of anisodamine was administrated in the anisodamine treatment group on the basis of conventional treatment. Acute lung injury scores, oxygenation index, PaO2, respiratory mechanic index, mechanical ventilation time, and the occurrence of adverse reactions in the two groups were observed. Acute lung injury scores and respiratory parameters were all significantly improved in the two groups of patients after the treatment (P < 0.05); compared with the conventional treatment group, the improvements of respiratory function in the anisodamine treatment group were more obvious (P < 0.05), the mechanical ventilation time was shorter (P < 0.05), and there was no significant adverse reaction. In conclusion, high dose of anisodamine contributed to improve the respiratory function of the patients with traumatic ALI.
AuthorsZheng Guoshou, Zhan Chengye, Li Zhihui, Luo Jinlong
JournalCell biochemistry and biophysics (Cell Biochem Biophys) Vol. 66 Issue 2 Pg. 365-9 (Jun 2013) ISSN: 1559-0283 [Electronic] United States
PMID23504631 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Solanaceous Alkaloids
  • Vasodilator Agents
  • anisodamine
Topics
  • APACHE
  • Acute Lung Injury (drug therapy, etiology)
  • Adult
  • Female
  • Humans
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Oxygen Consumption
  • Respiration, Artificial
  • Respiratory Mechanics
  • Solanaceous Alkaloids (therapeutic use)
  • Treatment Outcome
  • Vasodilator Agents (therapeutic use)
  • Wounds and Injuries (complications)

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