Abstract | PURPOSE: METHODS: Prospective interventional case series. Fourteen patients (14 eyes) affected by juxtafoveal choroidal neovascularization secondary to multifocal choroiditis were examined. All patients underwent a complete ophthalmologic examination, including measurement of best-corrected visual acuity using Early Treatment Diabetic Retinopathy Study charts, optical coherence tomography, and fluorescein angiography. The protocol treatment included a first injection, followed by repeated intravitreal bevacizumab injections over a 12-month follow-up period on the basis of optical coherence tomography parameters and angiographic features. RESULTS: Mean best-corrected visual acuity changed from 0.41 logarithm of the minimum angle of resolution (approximately corresponding to 20/51 Snellen equivalent), at baseline, to 0.16 ± 0.13 logarithm of the minimum angle of resolution (approximately corresponding to 20/28 Snellen equivalent), at the 12-month examination (P < 0.002). A functional improvement of at least 3 Early Treatment Diabetic Retinopathy Study lines was achieved by 6 eyes (43%) at the 12-month examination. Mean central macular thickness at baseline was 318 μm, reducing to 239 μm at the 12-month examination (P < 0.001). No eye showed choroidal neovascularization extension to the fovea. CONCLUSION:
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Authors | Maurizio B Parodi, Pierluigi Iacono, Ahamad Mansour, Umberto de Benedetto, Karl A Knutsson, Francesco Bandello, Focke Ziemssen, Thomas Ness, David Dodwell |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 33
Issue 5
Pg. 953-6
(May 2013)
ISSN: 1539-2864 [Electronic] United States |
PMID | 23503338
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
- Angiogenesis Inhibitors
- Antibodies, Monoclonal, Humanized
- Bevacizumab
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Topics |
- Adult
- Angiogenesis Inhibitors
(administration & dosage)
- Antibodies, Monoclonal, Humanized
(administration & dosage)
- Bevacizumab
- Choroidal Neovascularization
(drug therapy, etiology, physiopathology)
- Choroiditis
(complications, physiopathology)
- Female
- Humans
- Intravitreal Injections
- Male
- Middle Aged
- Prospective Studies
- Visual Acuity
(physiology)
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