Angiopoietin signaling in the vasculature.

Abstract

The angiopoietin (Ang) growth factors and the endothelial Tie receptors regulate blood and lymphatic vessel development, and vascular permeability, inflammation, angiogenic remodeling and tumor vascularization in adult tissues. The angiopoietins activate the Tie receptors in unique in trans complexes at endothelial cell-cell and cell-matrix contacts. In addition, integrins have been implicated in the regulation of Ang-Tie signaling. Recent interest has focused on the function of angiopoietin-2 and its inhibition in the tumor vasculature and also in other pathological conditions associated with endothelial dysfunction. Here we review the current understanding of the signaling functions of the Ang-Tie pathway and its potential for future development of targeted vascular therapeutics.

• Authors: Lauri Eklund, Pipsa Saharinen
• Journal: Experimental cell research (Exp Cell Res) Vol. 319 Issue 9 Pg. 1271-80 (May 15 2013) ISSN: 1090-2422 [Electronic] United States
• PMID: 23500414 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Angiopoietins

Topics

• Angiopoietins (physiology)
• Animals
• Cardiovascular Diseases (metabolism, pathology)
• Cardiovascular System (growth & development, metabolism, pathology)
• Endothelium, Vascular (metabolism)
• Extracellular Matrix (metabolism)
• Humans
• Lymphatic System (growth & development)
• Neovascularization, Physiologic
• Permeability
• Signal Transduction