A diagnostic conundrum: acute interstitial nephritis due to armodafinil versus acute cellular rejection in a renal transplant recipient--a case report.

Abstract

Acute interstitial nephritis is a well-recognized cause of acute kidney injury in native kidneys. While the most common etiology being drug-induced, other causes are infectious, autoimmune, and idiopathic forms of disease. Drug-induced acute interstitial nephritis is not only uncommon in renal transplant recipients but is difficult to diagnose as it mimics acute cellular rejection histologically. We have described herein a renal transplant recipient with acute kidney injury to highlight the difficulties to distinguish acute interstitial nephritis from acute cellular rejection.

• Authors: K M Baradhi, R Gohh
• Journal: Transplantation proceedings (Transplant Proc) Vol. 45 Issue 2 Pg. 845-7 (Mar 2013) ISSN: 1873-2623 [Electronic] United States
• PMID: 23498834 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Benzhydryl Compounds
• Central Nervous System Stimulants
• Modafinil

Topics

• Acute Disease
• Benzhydryl Compounds (adverse effects)
• Biopsy
• Central Nervous System Stimulants (adverse effects)
• Diagnosis, Differential
• Eosinophilia (chemically induced, diagnosis)
• Female
• Graft Rejection (diagnosis, immunology)
• Humans
• Immunity, Cellular
• Kidney (drug effects, immunology, pathology)
• Kidney Transplantation (adverse effects, immunology)
• Middle Aged
• Modafinil
• Nephritis, Interstitial (chemically induced, diagnosis)
• Predictive Value of Tests