Progression of Chiari I malformations while on growth hormone replacement: a report of two cases.

Abstract

PURPOSE:

The effect of growth hormone replacement on Chiari I malformation (CIM) associated with growth hormone deficiency is not clear.

CASE REPORTS:

Two patients are presented, who were found to have CIM and growth hormone deficiency. While on hormone replacement therapy, both experienced disease progression with development of syringomyelia and required surgical intervention.

CONCLUSION:

Growth hormone replacement for CIM associated with growth hormone deficiency does not uniformly halt or reverse syrinx progression. If a trial of hormone replacement is attempted, patients should be followed closely for progression of syringomyelia or the development of symptoms.

• Authors: Robert P Naftel, R Shane Tubbs, Joshua Y Menendez, W Jerry Oakes
• Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (Childs Nerv Syst) Vol. 29 Issue 12 Pg. 2291-4 (Dec 2013) ISSN: 1433-0350 [Electronic] Germany
• PMID: 23494658 (Publication Type: Case Reports, Journal Article)

Chemical References

• Human Growth Hormone

Topics

• Arnold-Chiari Malformation (complications, pathology)
• Child, Preschool
• Disease Progression
• Female
• Hormone Replacement Therapy (adverse effects)
• Human Growth Hormone (adverse effects)
• Humans
• Syringomyelia (etiology, pathology)