Abstract | BACKGROUND: METHODS: Data were extracted on infants with IHPS who were treated with atropine and/or surgery, from a nationwide administrative database through 2006-2008. Patient demographic data, treatment effects and length of hospital stay were analyzed in each treatment group. RESULTS: A total of 585 infants met the criteria for IHPS; 188 patients (32%) were initially treated with atropine (i.v. form, n = 180; oral form, n = 8), while 397 were treated with surgery as a first-line therapy. Of the 180 infants receiving i.v. atropine, 38 were withdrawn from medical management and subsequently underwent surgery. Thus, the overall success rate of i.v. atropine was 78.9% (142/180). Surgery had a success rate of 100%, and postoperative complications were found in 2.8% of patients (12/435). Medical management required longer hospital stay than surgery (mean, 13.5 days vs 8.0 days; P < 0.001). CONCLUSION: Surgery remains the suitable standard management option for IHPS, with its high success rate, minimal complications and shorter hospital stay compared with i.v. atropine therapy.
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Authors | Masato Takeuchi, Hideo Yasunaga, Hiromasa Horiguchi, Hideki Hashimoto, Shinya Matsuda |
Journal | Pediatrics international : official journal of the Japan Pediatric Society
(Pediatr Int)
Vol. 55
Issue 4
Pg. 488-91
(Aug 2013)
ISSN: 1442-200X [Electronic] Australia |
PMID | 23489384
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society. |
Chemical References |
- Parasympatholytics
- Atropine
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Topics |
- Atropine
(administration & dosage)
- Databases, Factual
- Digestive System Surgical Procedures
(methods)
- Female
- Follow-Up Studies
- Humans
- Infant
- Infusions, Intravenous
- Length of Stay
(statistics & numerical data)
- Male
- Parasympatholytics
(administration & dosage)
- Patient Discharge
(statistics & numerical data)
- Pyloric Stenosis, Hypertrophic
(therapy)
- Pylorus
(surgery)
- Retrospective Studies
- Treatment Outcome
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