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Adenosine A2A receptor antagonist istradefylline reduces daily OFF time in Parkinson's disease.

AbstractBACKGROUND:
We evaluated the efficacy and safety of istradefylline, a selective adenosine A2A receptor antagonist administered as adjunctive treatment to levodopa for 12 weeks in a double-blind manner in Parkinson's disease patients with motor complications in Japan.
METHODS:
A total of 373 subjects were randomized to receive placebo (n=126), istradefylline 20 mg/day (n=123), or istradefylline 40 mg/day (n=124). The primary efficacy variable was the change in daily OFF time. Other secondary variables were also evaluated.
RESULTS:
The change in daily OFF time was significantly reduced in the istradefylline 20 mg/day (-0.99 hours, P=.003) and istradefylline 40 mg/day (-0.96 hours, P=.003) groups compared with the placebo group (-0.23 hours). The most common adverse event was dyskinesia (placebo, 4.0%; istradefylline 20 mg/day, 13.0%; istradefylline 40 mg/day, 12.1%).
CONCLUSIONS:
Istradefylline reduced daily OFF time and was well tolerated in Japanese PD patients with motor complications on levodopa treatment.
AuthorsYoshikuni Mizuno, Tomoyoshi Kondo,
JournalMovement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 28 Issue 8 Pg. 1138-41 (Jul 2013) ISSN: 1531-8257 [Electronic] United States
PMID23483627 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Movement Disorder Society.
Chemical References
  • Adenosine A2 Receptor Antagonists
  • Purines
  • istradefylline
Topics
  • Adenosine A2 Receptor Antagonists (therapeutic use)
  • Aged
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Parkinson Disease (drug therapy)
  • Purines (therapeutic use)
  • Retrospective Studies
  • Treatment Outcome

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