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Scanning laser polarimetry in eyes with exfoliation syndrome.

AbstractPURPOSE:
To compare retinal nerve fiber layer thickness (RNFLT) of normotensive eyes with exfoliation syndrome (XFS) and healthy eyes.

METHODS:
Sixty-four consecutive individuals with XFS and normal office-time intraocular pressure (IOP) and 72 consecutive healthy controls were prospectively enrolled for a cross-sectional analysis in this hospital-based observational study. The GDx-VCC parameters (temporal-superior-nasal-inferior-temporal [TSNIT] average, superior average, inferior average, TSNIT standard deviation (SD), and nerve fiber indicator [NFI]) were compared between groups. Correlation between various clinical parameters and RNFLT parameters was investigated with Spearman coefficient. 

RESULTS:
The NFI, although within normal limits for both groups, was significantly greater in the XFS group compared to controls: the respective median and interquartile range (IQR) values were 25.1 (22.0-29.0) vs 15.0 (12.0-20.0), p<0.001. In the XFS group, all RNFLT values were significantly lower compared to controls (p<0.001). However, they were all within the normal clinical ranges for both groups: TSNIT average median (IQR): 52.8 (49.7-55.7) vs 56.0 (53.0-59.3) µm; superior average mean (SD): 62.3 (6.7) vs 68.8 (8.2) µm; inferior average mean (SD): 58.0 (7.2) vs 64.8 (7.7) µm, respectively. TSNIT SD was significantly lower in the XFS group, median (IQR): 18.1 (15.4-20.4) vs 21.0 (18.4-23.8), p<0.001. There was no systematic relationship between RNFLT and visual acuity, cup-to-disc ratio, IOP, central corneal thickness, Humphrey mean deviation, and pattern standard deviation in either group. 

CONCLUSIONS:
Compared to control eyes, polarimetry-determined RNFLT was lower in XFS eyes with normal IOP. Therefore, close monitoring of RNFLT may facilitate early identification of those XFS eyes that convert to exfoliative glaucoma.
AuthorsAntonios T Dimopoulos, Andreas Katsanos, Dimitrios G Mikropoulos, Theodoros Giannopoulos, Theodoros Empeslidis, Miguel A Teus, Gábor Holló, Anastasios G P Konstas
JournalEuropean journal of ophthalmology (Eur J Ophthalmol) 2013 Sep-Oct Vol. 23 Issue 5 Pg. 743-50 ISSN: 1724-6016 [Electronic] United States
PMID23483498 (Publication Type: Journal Article)
Topics
  • Aged
  • Case-Control Studies
  • Cross-Sectional Studies
  • Exfoliation Syndrome (pathology)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nerve Fibers (pathology)
  • Prospective Studies
  • Retinal Diseases (pathology)
  • Scanning Laser Polarimetry

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