Abstract | BACKGROUND: OBJECTIVE: Elucidating the joint-protective mechanisms of p38 inhibitors in rodent models of RA may have implications in the design of p38-based therapies for this disease. METHOD: This review highlights the tissue- and cell-specific complex interactions between p38 and pro-inflammatory cytokines. CONCLUSION: This review provides evidence that p38α and TNF-α are key partners in RA, and that inhibition of this kinase should be effective in treating this disease.
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Authors | Gabriel Mbalaviele, Joseph B Monahan |
Journal | Expert opinion on drug discovery
(Expert Opin Drug Discov)
Vol. 3
Issue 2
Pg. 163-72
(Feb 2008)
ISSN: 1746-0441 [Print] England |
PMID | 23480220
(Publication Type: Journal Article)
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