Cardiac surgery for ergotamine-induced multivalvular heart disease.

Abstract

Ergotamine is used to abort or prevent vascular headache. Valvular heart disease as an adverse effect of long-term ergotamine therapy has been rarely reported in the English literature, with only a few cases published. It is hypothesized that ergot-derived agents stimulate serotonergic receptors (5-HT2B), causing proliferation of myofibroblasts, with subsequent thickening of valve leaflets and chords. This case presentation aims at increasing clinicians' awareness of this potential complication.

• Authors: George Lazopoulos, George Papaioannou, Michael Kantartzis
• Journal: The Thoracic and cardiovascular surgeon (Thorac Cardiovasc Surg) Vol. 61 Issue 5 Pg. 435-7 (Aug 2013) ISSN: 1439-1902 [Electronic] Germany
• PMID: 23475795 (Publication Type: Case Reports, Journal Article)
• Copyright: Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Drug Combinations
• Serotonin 5-HT2 Receptor Agonists
• caffeine, ergotamine drug combination
• Caffeine
• Ergotamine

Topics

• Aortic Valve Insufficiency (chemically induced, surgery)
• Caffeine (adverse effects)
• Cardiac Valve Annuloplasty
• Cell Proliferation (drug effects)
• Drug Combinations
• Echocardiography, Doppler, Color
• Ergotamine (adverse effects)
• Female
• Heart Valve Diseases (chemically induced, diagnosis, surgery)
• Heart Valve Prosthesis Implantation
• Heart Valves (drug effects, pathology, surgery)
• Humans
• Middle Aged
• Mitral Valve Insufficiency (chemically induced, surgery)
• Myofibroblasts (drug effects, pathology)
• Serotonin 5-HT2 Receptor Agonists (adverse effects)
• Treatment Outcome
• Tricuspid Valve Insufficiency (chemically induced, surgery)