Abstract | AIM: METHODS: RESULTS: MSCs transplantation significantly reduced serum S-100B level, and improved neurological function after global cerebral ischemia compared to the PBS-treated group. The MSCs injected migrated into the ischemic brains, and were observed mainly in the cerebral cortex. Furthermore, MSCs transplantation significantly increased the expression of TSG-6, and reduced the expression of neutrophil elastase and proinflammatory cytokines in the cerebral cortex. Intracerebroventricular injection of TSG-6 reproduced the beneficial effects of MSCs transplantation in rats with global cerebral ischemia. CONCLUSION: MSCs transplantation improves functional recovery and reduces inflammatory responses in rats with global cerebral ischemia, maybe via upregulation of TSG-6 expression.
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Authors | Qing-ming Lin, Shen Zhao, Li-li Zhou, Xiang-shao Fang, Yue Fu, Zi-tong Huang |
Journal | Acta pharmacologica Sinica
(Acta Pharmacol Sin)
Vol. 34
Issue 6
Pg. 784-92
(Jun 2013)
ISSN: 1745-7254 [Electronic] United States |
PMID | 23474707
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cell Adhesion Molecules
- Inflammation Mediators
- S100 Calcium Binding Protein beta Subunit
- Tnfaip6 protein, rat
- Leukocyte Elastase
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Topics |
- Animals
- Blotting, Western
- Brain Ischemia
(physiopathology, therapy)
- Cell Adhesion Molecules
(administration & dosage, genetics, metabolism)
- Cerebral Cortex
(metabolism, pathology)
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Inflammation
(pathology, therapy)
- Inflammation Mediators
(metabolism)
- Injections, Intravenous
- Leukocyte Elastase
(genetics, metabolism)
- Male
- Mesenchymal Stem Cell Transplantation
(methods)
- Rats
- Rats, Sprague-Dawley
- Reverse Transcriptase Polymerase Chain Reaction
- S100 Calcium Binding Protein beta Subunit
(blood)
- Time Factors
- Treatment Outcome
- Up-Regulation
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