Dabigatran overdose secondary to acute kidney injury and amiodarone use.

Abstract

Oral direct thrombin inhibitors have improved treatment of non-valvular atrial fibrillation. Safety concerns have been raised since there is no antidote for treatment of secondary haemorrhages and the absence of widely validated test to monitor drug levels. We present a case of dabigatran overdose in an 82-year-old female who was treated with a seemingly appropriate dose.

• Authors: Christos Fountzilas, Jerry George, Randy Levine
• Journal: The New Zealand medical journal (N Z Med J) Vol. 126 Issue 1370 Pg. 110-2 (Mar 01 2013) ISSN: 1175-8716 [Electronic] New Zealand
• PMID: 23474519 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Antithrombins
• Benzimidazoles
• Fibrin Fibrinogen Degradation Products
• fibrin fragment D
• beta-Alanine
• Fibrinogen
• Creatinine
• Dabigatran
• Amiodarone

Topics

• Acute Kidney Injury (complications)
• Aged, 80 and over
• Amiodarone (therapeutic use)
• Anti-Arrhythmia Agents (therapeutic use)
• Antithrombins (administration & dosage, adverse effects, pharmacokinetics)
• Atrial Fibrillation (drug therapy)
• Benzimidazoles (administration & dosage, adverse effects, pharmacokinetics)
• Creatinine (analysis)
• Dabigatran
• Drug Overdose
• Female
• Fibrin Fibrinogen Degradation Products (analysis)
• Fibrinogen (analysis)
• Humans
• Thrombin Time
• beta-Alanine (administration & dosage, adverse effects, analogs & derivatives, pharmacokinetics)