Exercise and coronary heart disease risk markers in South Asian and European men.

Abstract

PURPOSE:

South Asians have a higher-than-average risk of CHD. The reasons for this are unclear, but physical inactivity and/or poor responsiveness to exercise may play a role. This study compared the effect of prior exercise on postprandial triacylglycerol (TAG), glucose, insulin, interleukin-6, and soluble intercellular adhesion molecule-1 concentrations in South Asian and European men.

METHODS:

Ten healthy South Asian men (i.e., nine Indian men and one Pakistani man) and 10 healthy European men age 20 to 28 yr completed two 2-d trials (exercise and control) in a randomized crossover design. On the afternoon of day 1 of the exercise trial, participants ran on a treadmill for 60 min at approximately 70% of maximal oxygen uptake. Participants rested on day 1 of the control trial. On day 2 of both trials, participants rested and consumed high-fat (57% of energy content) test meals for breakfast (0 h) and lunch (4 h). Fourteen venous blood samples were collected from a cannula between 0 and 9 h for metabolic measurements.

RESULTS:

Three-way ANOVA identified higher (P < 0.05) postprandial TAG and insulin concentrations in South Asian versus European men. Exercise lowered postprandial TAG and interleukin-6 and elevated soluble intercellular adhesion molecule-1 concentrations. An interaction effect indicated a greater decrease (22% vs 10%) in TAG area under the concentration versus time curve after exercise in South Asian than in European men.

CONCLUSIONS:

Postprandial TAG and insulin responses to high-fat meals were elevated in these South Asian men, but acute exercise was equally, if not more, effective for reducing postprandial lipemia in South Asian than in European men.

• Authors: Saravana Pillai Arjunan, Nicolette Claire Bishop, Alvaro Reischak-Oliveira, David John Stensel
• Journal: Medicine and science in sports and exercise (Med Sci Sports Exerc) Vol. 45 Issue 7 Pg. 1261-8 (Jul 2013) ISSN: 1530-0315 [Electronic] United States
• PMID: 23470315 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Triglycerides

Topics

• Adult
• Analysis of Variance
• Asian People
• Biomarkers (blood)
• Coronary Disease (blood, ethnology, etiology, prevention & control)
• Cross-Over Studies
• Diet, High-Fat
• Exercise Test
• Humans
• Hypertriglyceridemia (complications, ethnology, prevention & control)
• India (ethnology)
• Male
• Meals
• Pakistan (ethnology)
• Postprandial Period (physiology)
• Risk Factors
• Running (physiology)
• Triglycerides (blood)
• White People