BRCA1 protein expression and its correlation with ER/PR status in sporadic and familial breast cancer in Eastern Indian patients--a hospital based study.

Abstract

BRCA1 gene expression in familial breast cancer is mainly focused on mutational analysis. However in sporadic cancers BRCA1 protein expression is the main area of interest because somatic inactivation of one allele of the gene is likely to occur during the oestrogen mediated proliferation at puberty and subsequent tumourigenic events take place in the same cell. Standard immunohistochemical analysis was used to assess BRCA1 and oestrogen/progesterone receptor (ER/PR) status in familial and sporadic breast cancer patients and correlation of BRCA1 protein expression with histopathological features ER/PR status was studied in these tumours. One hundred and seventy-seven sporadic tumours (group A) and 28 familial tumours (patients with history of breast cancer in first or second degree relative ie, group B) were studied. In group A, 61 tumours had absent/reduced BRCA 1 protein expression; 30 (49%) out of these were negative for ER/PR receptors. In group B, 18 patients had absent/reduced BRCA1 protein expression, and 10 (55.6%) out of these, were ER/PR negative. Overall in 2 groups, 82 tumours were of grade 1, 61 tumours of grade 2 and 62 tumours were of grade 3 differentiation. Test of proportion showed that percentage of ER/PR negativity is significantly higher than ER/PR positivity in sporadic as well as in familial tumours with absent/ reduced BRCA 1 protein expression (p < 0.05). Sporadic tumours with deranged BRCA1 protein expression like familial tumours have more unfavourable histopathological characteristics and are likely to be of higher grade and oestrogen receptor negative

• Authors: M Ashraf, J K Jha, N Mukherjee, C K Panda, S Nayak, T S Jadhav, N Dikshit, N C Nath, J Chakraborty, J Biswas
• Journal: Journal of the Indian Medical Association (J Indian Med Assoc) Vol. 109 Issue 12 Pg. 873-8 (Dec 2011) ISSN: 0019-5847 [Print] India
• PMID: 23469566 (Publication Type: Journal Article)

Chemical References

• BRCA1 Protein
• Receptors, Estrogen
• Receptors, Progesterone

Topics

• Adult
• BRCA1 Protein (metabolism)
• Breast Neoplasms (genetics, metabolism, pathology)
• Carcinoma (genetics, metabolism, pathology)
• Female
• Gene Expression
• Humans
• India
• Male
• Middle Aged
• Neoplasm Grading
• Prospective Studies
• Receptors, Estrogen (metabolism)
• Receptors, Progesterone (metabolism)
• Young Adult