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Characterization of anamnestic T-cell responses induced by conventional vaccines against contagious bovine pleuropneumonia.

Abstract
A better understanding of how T1 vaccination confers immunity would facilitate the rational design of improved vaccines against contagious bovine pleuropneumonia (CBPP). We show here that mycoplasmas-induced recall proliferation and IFN-γ responses are detected in cattle that received multiple shots of T1 vaccines. These anamnestic responses were under the strict control of CD4(+) T lymphocytes. Moreover, CD62L expression indicated that both CD4(+) effector memory (Tem) and central memory (Tcm) T lymphocytes are elicited in these animals. Comparative analysis with data from cattle that completely recovered from CBPP infection revealed similar anamnestic T-cell responses albeit at a lower magnitude for T1-vaccinated animals, particularly in the Tcm compartment. In conclusion, we discuss how our current understanding of T-cell responses will contribute to ongoing efforts for the improvement of future CBPP vaccines.
AuthorsPhilippe Totte, Aboubakar Yaya, Amadou Sery, Hezron Wesonga, Abel Wade, Jan Naessens, Mamadou Niang, François Thiaucourt
JournalPloS one (PLoS One) Vol. 8 Issue 2 Pg. e57509 ( 2013) ISSN: 1932-6203 [Electronic] United States
PMID23469008 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Bacterial Vaccines
Topics
  • Animals
  • Bacterial Vaccines (immunology, therapeutic use)
  • CD4-Positive T-Lymphocytes (immunology)
  • Cattle
  • Cattle Diseases (immunology, prevention & control)
  • Enzyme-Linked Immunosorbent Assay
  • Flow Cytometry
  • Immunologic Memory
  • Pleuropneumonia, Contagious (immunology, prevention & control)

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