Abstract |
A better understanding of how T1 vaccination confers immunity would facilitate the rational design of improved vaccines against contagious bovine pleuropneumonia (CBPP). We show here that mycoplasmas-induced recall proliferation and IFN-γ responses are detected in cattle that received multiple shots of T1 vaccines. These anamnestic responses were under the strict control of CD4(+) T lymphocytes. Moreover, CD62L expression indicated that both CD4(+) effector memory (Tem) and central memory (Tcm) T lymphocytes are elicited in these animals. Comparative analysis with data from cattle that completely recovered from CBPP infection revealed similar anamnestic T-cell responses albeit at a lower magnitude for T1-vaccinated animals, particularly in the Tcm compartment. In conclusion, we discuss how our current understanding of T-cell responses will contribute to ongoing efforts for the improvement of future CBPP vaccines.
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Authors | Philippe Totte, Aboubakar Yaya, Amadou Sery, Hezron Wesonga, Abel Wade, Jan Naessens, Mamadou Niang, François Thiaucourt |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 2
Pg. e57509
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23469008
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Bacterial Vaccines
(immunology, therapeutic use)
- CD4-Positive T-Lymphocytes
(immunology)
- Cattle
- Cattle Diseases
(immunology, prevention & control)
- Enzyme-Linked Immunosorbent Assay
- Flow Cytometry
- Immunologic Memory
- Pleuropneumonia, Contagious
(immunology, prevention & control)
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