Abstract | BACKGROUND: Topical application of corticosteroids also has an influence on skin barrier impairment. Physiological lipid mixtures, such as multi-lamellar emulsion (MLE) containing a natural lipid component leads to effective recovery of the barrier function. OBJECTIVE: The purpose of this study was to conduct an evaluation of the therapeutic efficacy and skin barrier protection of topical mometasone furoate in MLE. METHODS: A multi-center randomized, double-blind, controlled study was performed to assess the efficacy and safety of mometasone furoate cream in MLE for Korean patients with eczema. The study group included 175 patients with eczema, who applied either mometasone furoate in MLE cream or methylprednisolone aceponate cream for 2 weeks. Treatment efficacy was evaluated using the physician's global assessment of clinical response ( PGA), trans-epidermal water loss (TEWL), and visual analogue scale (VAS) for pruritus. Patients were evaluated using these indices at days 4, 8, and 15. RESULTS: CONCLUSION:
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Authors | Duk Han Kim, Hyun Jong Lee, Chun Wook Park, Kyu Han Kim, Kwang Hoon Lee, Byung In Ro, Sang Hyun Cho |
Journal | Annals of dermatology
(Ann Dermatol)
Vol. 25
Issue 1
Pg. 17-22
(Feb 2013)
ISSN: 1013-9087 [Print] Korea (South) |
PMID | 23467551
(Publication Type: Journal Article)
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