Pan-nitinol occluder and special delivery device for closure of patent ductus arteriosus: a canine-model feasibility study.

Abstract

The aim of this study was to evaluate a new type of occluder for patent ductus arteriosus. Patent ductus arteriosus was established in a canine model by anastomosing a length of autologous jugular vein to the descending aorta and the left pulmonary artery in an end-to-side fashion. Transcatheter closure of each patent ductus arteriosus was performed on 10 dogs, which were then monitored for as long as 6 months with aortography, echocardiography, and histologic evaluation. Transcatheter closure with use of the novel pan-nitinol device was successful in all canine models. Postoperative echocardiography showed that the location and shape of the occluders were normal, without any residual shunting. Further histologic evaluation confirmed that the occluder surface was completely endothelialized 3 months after implantation. Transcatheter patent ductus arteriosus closure with the pan-nitinol occluder can be performed safely and successfully in a canine model and shows good biological compatibility and low mortality rates.

• Authors: Hai-bin Jiang, Yuan Bai, Gang-jun Zong, Lin Han, Wei-ping Li, Yang Lu, Yong-wen Qin, Xian-xian Zhao
• Journal: Texas Heart Institute journal (Tex Heart Inst J) Vol. 40 Issue 1 Pg. 30-3 ( 2013) ISSN: 1526-6702 [Electronic] United States
• PMID: 23466429 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Alloys
• nitinol

Topics

• Alloys
• Anastomosis, Surgical
• Animals
• Aorta, Thoracic (surgery)
• Aortography
• Cardiac Catheterization (instrumentation)
• Disease Models, Animal
• Dogs
• Ductus Arteriosus, Patent (diagnosis, etiology, therapy)
• Echocardiography
• Equipment Design
• Feasibility Studies
• Jugular Veins (surgery)
• Materials Testing
• Microscopy, Electron, Scanning
• Pulmonary Artery (surgery)
• Septal Occluder Device
• Time Factors