Serum microRNAs as potential biomarkers of mandibular prognathism.

Abstract

OBJECTIVES:

The aim of the study was to determine whether the expression levels of specific circulating serum microRNAs (miRNAs) are associated with mandibular prognathism (MP).

METHODS:

Sixty subjects in the early permanent dentition stage and 23 in the mixed dentition stage with MP were identified. Sixty-eight normal control subjects in the early permanent dentition stage and 24 in the mixed dentition stage were recruited for comparison. According to the microarray-based expression profiling, four serum miRNAs (let-7i-3p, miR-595, miR-16-2-3p, and miR-367-5p) were validated.

RESULTS:

In the MP groups, let-7i-3p was significantly over-expressed in subjects in the early permanent (P < 0.0005) and mixed (P < 0.001) dentitions, and miR-595 was significantly under-expressed (P < 0.004) in subjects in the early permanent (P < 0.004) and mixed (P < 0.0005) dentitions, compared with normal control groups. Multiple logistic regression analysis and receiver operating characteristic curve analysis revealed that let-7i-3p and miR-595 were able to significantly discriminate MP subjects from normal controls.

CONCLUSION:

Let-7i-3p and miR-595 could be potential, non-invasive biomarkers for the accurate early detection and diagnosis of MP, which may result in improved clinical management.

• Authors: Y Gu, Y Zhang, C Zhao, Y Pan, R J Smales, H Wang, Y Ni, H Zhang, J Ni, J Ma, L Wang
• Journal: Oral diseases (Oral Dis) Vol. 20 Issue 1 Pg. 55-61 (Jan 2014) ISSN: 1601-0825 [Electronic] Denmark
• PMID: 23465220 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Biomarkers
• MicroRNAs

Topics

• Adolescent
• Biomarkers (blood)
• Child
• Female
• Humans
• Male
• MicroRNAs (blood)
• Pilot Projects
• Prognathism (blood, diagnosis)