Abstract | OBJECTIVE: To review the human and veterinary literature on the role of phosphorus in the pathophysiology of chronic kidney disease (CKD) and to explore why control of plasma phosphorus concentration is an important goal in the management of patients with this disease. DATA SOURCES: Human and veterinary studies, reviews, clinical reports, textbooks, and recent research findings focused on phosphate homeostasis and CKD patient management. HUMAN DATA SYNTHESIS: VETERINARY DATA SYNTHESIS: Cross-sectional studies of naturally occurring CKD in dogs and cats have shown hyperphosphatemia and SRHP to be highly prevalent and associated with increased morbidity and mortality in these patients. Experimental studies of surgically induced renal impairment in the dog and cat, and cases of naturally occurring CKD have emphasized the ability of renal care diets to modify plasma phosphorus and parathyroid hormone concentrations. Evidence from these studies indicates that maintaining plasma phosphorus concentrations to within the International Renal Interest Society targets for CKD patients improves survival time and reduces clinical manifestations of hyperphosphatemia and SRHP. CONCLUSIONS: The maintenance of plasma phosphorus concentrations in to within the International Renal Interest Society targets is recommended in management of CKD patients. The discovery of the phosphatonins has improved understanding of the mechanisms involved in phosphorus homeostasis and SRHP and may lead to improved ability to monitor and manage these patients.
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Authors | Rebecca F Geddes, Natalie C Finch, Harriet M Syme, Jonathan Elliott |
Journal | Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
(J Vet Emerg Crit Care (San Antonio))
2013 Mar-Apr
Vol. 23
Issue 2
Pg. 122-33
ISSN: 1476-4431 [Electronic] United States |
PMID | 23464730
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | © Veterinary Emergency and Critical Care Society 2013. |
Chemical References |
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Topics |
- Animals
- Humans
- Hyperphosphatemia
(veterinary)
- Phosphorus
(blood, metabolism)
- Renal Insufficiency, Chronic
(physiopathology, veterinary)
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