Reflux symptoms and side effects among patients with gastroesophageal reflux disease at baseline, during treatment with PPIs, and after Nissen fundoplication.

Abstract

BACKGROUND:

There are no prospective studies available on the behavior of extraesophageal and esophageal symptoms and treatment-related side effects in patients without effective antireflux medication, receiving the most effective antireflux medication, and after laparoscopic fundoplication.

METHODS:

Extraesophageal and esophageal reflux symptoms and treatment-related side effects were assessed in 60 patients while they were on no effective antireflux medication (three-week washout period), after three month of treatment with double-dose esomeprazole, and 3 months after laparoscopic Nissen fundoplication. Esophageal and extraesophageal reflux symptoms, rectal flatulence, and bloating were analyzed with the visual analog scale. In addition, dysphagia, rectal flatulence, and bloating were recorded as none, mild, moderate, or severe.

RESULTS:

Both extraesophageal and esophageal reflux symptoms decreased after treatment with esomeprazole and were further reduced after fundoplication. Dysphagia and flatulence did not increase from baseline after surgery. Bloating decreased both after treatment with esomeprazole and after fundoplication. In contrast, dysphagia and increased flatus were found more often after surgery than during treatment with esomeprazole. Dysphagia and rectal flatulence were less common during treatment with esomeprazole than at baseline or after surgery.

CONCLUSIONS:

Both extraesophageal and esophageal reflux symptoms decreased after treatment with esomeprazole and were reduced further after fundoplication. Any treatment-related side effect was not increased after surgery when compared to baseline. However, compared to esomeprazole there was more dysphagia and flatulence after fundoplication.

• Authors: Tuomo Rantanen, Toni Kiljander, Paulina Salminen, Arto Ranta, Niku Oksala, Ilmo Kellokumpu
• Journal: World journal of surgery (World J Surg) Vol. 37 Issue 6 Pg. 1291-6 (Jun 2013) ISSN: 1432-2323 [Electronic] United States
• PMID: 23463398 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Proton Pump Inhibitors
• Esomeprazole

Topics

• Esomeprazole (therapeutic use)
• Female
• Finland
• Flatulence (etiology)
• Fundoplication (methods)
• Gastroesophageal Reflux (drug therapy, physiopathology, surgery)
• Humans
• Laparoscopy (methods)
• Male
• Proton Pump Inhibitors (therapeutic use)
• Treatment Outcome