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Effect of allergen inhalation on airway oxidant stress, using exhaled breath condensate 8-isoprostane, in mild asthma.

AbstractOBJECTIVE:
Exhaled breath condensate (EBC) 8-isoprostane concentrations are increased in asthma, but it is not known if they acutely change following bronchoprovocation. The objective of this study was to evaluate EBC 8-isoprostane concentrations following allergen-induced bronchoprovocation in asthma.
METHODS:
This comparison study included eight mild atopic asthmatics and six controls. Asthmatics were challenged with inhaled specific allergen, methacholine, and irrelevant allergen in random order. Controls were challenged with irrelevant allergen. EBCs collected at 0, 3, 6, 9, and 23 hours by the R-tube method were measured for 8-isoprostanes by ELISA technique. Repeated measures ANOVA technique was used for analysis.
RESULTS:
EBC 8-isoprostane concentrations did not change following any inhalational challenge, as compared to baseline, in either asthmatics or controls.
CONCLUSIONS:
EBC 8-isoprostane concentrations do not acutely change following bronchoprovocation in subjects with mild asthma.
AuthorsAkshay Sood, Clifford Qualls, JeanClare Seagrave, Jacob McDonald, Rugia Shohreh, Annalisa Chiavaroli, Mark Schuyler
JournalThe Journal of asthma : official journal of the Association for the Care of Asthma (J Asthma) Vol. 50 Issue 5 Pg. 449-56 (Jun 2013) ISSN: 1532-4303 [Electronic] England
PMID23461590 (Publication Type: Journal Article)
Chemical References
  • Allergens
  • 8-epi-prostaglandin F2alpha
  • Dinoprost
Topics
  • Administration, Inhalation
  • Adult
  • Allergens (immunology)
  • Asthma (metabolism)
  • Breath Tests
  • Bronchi (metabolism)
  • Dinoprost (analogs & derivatives, analysis)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Middle Aged
  • Oxidative Stress
  • Radioimmunoassay

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