Abstract | PURPOSE: METHODS: This retrospective medical record review of consecutive CSC patients treated with RFPDT (full-dose verteporfin and laser fluence of 25 J/cm(2)) examined 22 eyes of 21 patients (20 males and one female). All patients were followed-up for 1 year. Best-corrected visual acuity (BCVA), complete resolution of subretinal fluid (CR of SRF), central retinal thickness (CRT), the outer nuclear layer (ONL) thickness, and the photoreceptor inner and outer segments (IS/OS) line determined by optical coherence tomography imaging were evaluated at baseline, 1, 3, 6, 9, and 12 months after initial RFPDT. RESULTS: A single RFPDT session was performed in all cases during a 12-month period. CR of SRF was identified in all patients. BCVA significantly improved between 3 and 12 months (P < 0.05). The CRT significantly decreased between 1 and 12 months. A significantly thicker ONL was observed at 1 month, and 17 eyes (77.2 %) showed recovery of the continuous foveal IS/OS line. ONL thickness was correlated with BCVA at 12 months (P < 0.01). Stepwise analysis indicated that pre-treatment BCVA (P < 0.01) and ONL thickness (P < 0.01) were significant predictive factors for BCVA at 12 months. Neither ocular nor systemic adverse effects were observed during the follow-up period. CONCLUSION: RFPDT appears to be an effective treatment method for CSC. ONL thickness is an important visual predictive factor of RFPDT for CSC.
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Authors | Yasuhiro Ohkuma, Takaaki Hayashi, Tsutomu Sakai, Akira Watanabe, Hiroshi Tsuneoka |
Journal | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
(Graefes Arch Clin Exp Ophthalmol)
Vol. 251
Issue 8
Pg. 1909-17
(Aug 2013)
ISSN: 1435-702X [Electronic] Germany |
PMID | 23456099
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Photosensitizing Agents
- Porphyrins
- Verteporfin
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Topics |
- Adult
- Aged
- Central Serous Chorioretinopathy
(diagnosis, drug therapy, physiopathology)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Photochemotherapy
- Photosensitizing Agents
(therapeutic use)
- Porphyrins
(therapeutic use)
- Prognosis
- Retina
(pathology)
- Retrospective Studies
- Subretinal Fluid
- Tomography, Optical Coherence
- Treatment Outcome
- Verteporfin
- Visual Acuity
(physiology)
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