Abstract | OBJECT: METHODS: We performed a literature search to identify studies that investigated the effects of clodronate treatment on early breast cancer. Random and fixed-effect meta-analytical models were used where indicated and between-study heterogeneity was assessed. The primary study end-points were overall survival. Secondary end-points were bone metastasis-free survival and non-skeletal metastasis (mainly visceral metastases) free survival. RESULTS: Four randomised controlled trials met the inclusion criteria. Risk ratio (95% confidence interval (CI)) of overall survival was 0.84 (0.56-1.26); risk ratio (95% CI) of bone metastasis-free survival was 0.77 (0.58-1.02); risk ratio (95% CI) of non-bone metastasis-free survival was 0.89 (0.61-1.30). Outcomes after sensitivity analysis were: risk ratio (95% CI) of overall survival was 0.71 (0.52-0.96); risk ratio (95% CI) of bone metastasis-free survival was 0.70 (0.56-0.86); risk ratio (95% CI) of non-bone metastasis-free survival was 0.76 (0.64-0.92). CONCLUSION: Compared with the control arm, adjuvant treatment with clodronate may improve the overall survival, bone metastasis-free survival and non-bone metastasis-free (mainly visceral metastases) survival in patients with early breast cancer. However, further meta-analyses involving all known randomised trials with analysis of sub-groups by age or menopausal status, accessing original trial data, should be performed.
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Authors | Jianhong Zhu, Yayuan Zheng, Zhikun Zhou |
Journal | European journal of cancer (Oxford, England : 1990)
(Eur J Cancer)
Vol. 49
Issue 9
Pg. 2086-92
(Jun 2013)
ISSN: 1879-0852 [Electronic] England |
PMID | 23452992
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Bone Density Conservation Agents
- Clodronic Acid
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Topics |
- Administration, Oral
- Adult
- Aged
- Antineoplastic Agents
(administration & dosage)
- Bone Density Conservation Agents
(administration & dosage)
- Bone Neoplasms
(drug therapy, mortality, secondary)
- Breast Neoplasms
(drug therapy, mortality)
- Clodronic Acid
(administration & dosage)
- Disease-Free Survival
- Female
- Humans
- Middle Aged
- Prospective Studies
- Randomized Controlled Trials as Topic
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