Effect of the treatment with alpha-macroglobulin on the development of experimental pancreatitis.

Abstract

UNLABELLED:

Alpha-macroglobulins are proteinase inhibitors. Monofluorophosphate increases alpha-macroglobulin levels in plasma, inducing a higher survival rate and lower pancreatic damage in rats with pancreatitis. The aim of this study was to evaluate the effect of alpha-macroglobulin on the development of pancreatitis. Pancreatitis was surgically induced in Sprague-Dawley rats divided into groups of 16 rats each and -subjected to the following intravenous treatments for 3 days:

CONTROLS:

pancreatitis without treatment, Enriched plasma: pancreatitis+-alpha-macroglobulin-enriched plasma, Normal plasma: pancreatitis+plasma with normal levels of alpha-macroglobulin, Saline Solution: pancreatitis+saline solution, Purified alpha-macroglobulin: pancreatitis+purified alpha-macroglobulin. After 14 days pancreatic damage was assessed using a score that measures: edema, fibrin, neutrophils, mononuclear leukocytes, necrosis, vascular congestion, thrombosis, hemorrhage and fibrosis. Pancreatic damage decreased and the percentage of animals with pancreatitis was lower in enriched-plasma and purified alpha-macroglobulin groups. We conclude that the intravenous administration of alpha-macroglobulins causes a reduction in the histological damage produced by pancreatitis.

• Authors: V E Di Loreto, S M Roma, A Rigalli
• Journal: Drug research (Drug Res (Stuttg)) Vol. 63 Issue 2 Pg. 90-3 (Feb 2013) ISSN: 2194-9379 [Print] Germany
• PMID: 23447080 (Publication Type: Journal Article)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• alpha-Macroglobulins

Topics

• Animals
• Male
• Pancreas (pathology)
• Pancreatitis (drug therapy, pathology)
• Rats
• Rats, Sprague-Dawley
• alpha-Macroglobulins (therapeutic use)