Epstein-Barr virus associated smooth muscle tumors in post transplant pediatric patients two cases of rare locations, and review of the literature.

Epstein-Barr virus (EBV) may present few or no symptoms in immunocompetent individuals; however, in immunocompromised patients as in the case of AIDS and post-transplant patients, the virus occasionally stimulates neoplastic transformations. Epstein-Barr virus may play a role in the development of smooth muscle tumors (SMT). In the case of Epstein-Barr associated smooth muscle tumors (EBV+SMT), the virus is thought to be the leading factor to the tumorigenic pathway. We report two pediatric patients (6 and 13 years old) who underwent liver transplantation and developed EBV+SMT in the colon and orbit. These two cases represent rare locations for this kind of lesion.
AuthorsNancy Elawabdeh, Brent M Cone, Carlos R Abramowsky, David M Wrubel, Hans Grossniklaus, Joseph Walrath, Maaman Z Bashir, Bahig M Shehata
JournalFetal and pediatric pathology (Fetal Pediatr Pathol) Vol. 32 Issue 3 Pg. 184-91 (Jun 2013) ISSN: 1551-3823 [Electronic] England
PMID23445451 (Publication Type: Case Reports, Journal Article)
  • Adolescent
  • Child
  • Colonic Neoplasms (pathology, virology)
  • Epstein-Barr Virus Infections (complications, pathology)
  • Female
  • Humans
  • Immunocompromised Host
  • Leiomyoma (pathology, virology)
  • Liver Transplantation (adverse effects)
  • Orbital Neoplasms (pathology, virology)
  • Postoperative Complications

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