Abstract | BACKGROUND: OBJECTIVE: To compare the pharmacokinetics of clindamycin in whole skin homogenates of normal dogs when administered orally at two dosage regimens (5.5 mg/kg BW, twice daily and 11 mg/kg BW, once daily). ANIMALS AND METHODS: Skin biopsies were obtained from six laboratory beagles before, 3, 6 and 12 h after the first and the fifth dose of clindamycin at the former regimen, as well as before, 3, 6, 12 and 24 h after the first and third dose at the latter regimen. Tissue was homogenized and clindamycin concentrations were measured by reverse-phase high-performance liquid chromatography coupled with mass spectrometry. Results were analyzed using Student's t-test at a level of significance of 0.05. RESULTS: Maximal concentration and area under the concentration-time curve, but not their relevant dose-normalized values, were higher at the dosage regimen of 11 mg/kg BW, once daily than at 5.5 mg/kg BW twice daily. CONCLUSIONS: The pharmacokinetic profile of clindamycin is at least equal, if not better, when this antimicrobial is administered at 11 mg/kg BW, once daily.
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Authors | Manolis N Saridomichelakis, Labrini V Athanasiou, Manolis K Chatzis, Michel Salame, Vassilis Katsoudas, Ioannis S Pappas |
Journal | The veterinary quarterly
(Vet Q)
Vol. 33
Issue 1
Pg. 7-12
( 2013)
ISSN: 1875-5941 [Electronic] England |
PMID | 23445168
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Clindamycin
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Topics |
- Administration, Oral
- Animals
- Anti-Bacterial Agents
(administration & dosage, pharmacokinetics)
- Area Under Curve
- Chromatography, High Pressure Liquid
- Clindamycin
(administration & dosage, pharmacokinetics)
- Cross-Over Studies
- Dogs
(metabolism)
- Dose-Response Relationship, Drug
- Female
- Male
- Mass Spectrometry
- Skin
(drug effects, metabolism)
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