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Concentrations of clindamycin hydrochloride in homogenates of normal dog skin when administered at two oral dosage regimens.

AbstractBACKGROUND:
Clindamycin is frequently used for the treatment of bacterial pyoderma.
OBJECTIVE:
To compare the pharmacokinetics of clindamycin in whole skin homogenates of normal dogs when administered orally at two dosage regimens (5.5 mg/kg BW, twice daily and 11 mg/kg BW, once daily).
ANIMALS AND METHODS:
Skin biopsies were obtained from six laboratory beagles before, 3, 6 and 12 h after the first and the fifth dose of clindamycin at the former regimen, as well as before, 3, 6, 12 and 24 h after the first and third dose at the latter regimen. Tissue was homogenized and clindamycin concentrations were measured by reverse-phase high-performance liquid chromatography coupled with mass spectrometry. Results were analyzed using Student's t-test at a level of significance of 0.05.
RESULTS:
Maximal concentration and area under the concentration-time curve, but not their relevant dose-normalized values, were higher at the dosage regimen of 11 mg/kg BW, once daily than at 5.5 mg/kg BW twice daily.
CONCLUSIONS:
The pharmacokinetic profile of clindamycin is at least equal, if not better, when this antimicrobial is administered at 11 mg/kg BW, once daily.
AuthorsManolis N Saridomichelakis, Labrini V Athanasiou, Manolis K Chatzis, Michel Salame, Vassilis Katsoudas, Ioannis S Pappas
JournalThe veterinary quarterly (Vet Q) Vol. 33 Issue 1 Pg. 7-12 ( 2013) ISSN: 1875-5941 [Electronic] England
PMID23445168 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Bacterial Agents
  • Clindamycin
Topics
  • Administration, Oral
  • Animals
  • Anti-Bacterial Agents (administration & dosage, pharmacokinetics)
  • Area Under Curve
  • Chromatography, High Pressure Liquid
  • Clindamycin (administration & dosage, pharmacokinetics)
  • Cross-Over Studies
  • Dogs (metabolism)
  • Dose-Response Relationship, Drug
  • Female
  • Male
  • Mass Spectrometry
  • Skin (drug effects, metabolism)

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