Abstract |
A double-masked, placebo-controlled, randomized study was done to assess the safety and clinical and quantitative microbiologic efficacy of 1% mercuric oxide (yellow) ophthalmic ointment in the treatment of eyelid infections, i.e., bacterial blepharitis. A total of 39 patients with bacterial counts and clinical signs indicative of eyelid infection were treated twice daily for 7 days. Clinical biomicroscopic examination and quantitative microbiologic cultures were done just prior to initiation of treatment and again on days 3 and 7. Statistical analysis revealed a significant improvement in the clinical signs, bacterial count, cure rate, and improvement rate for subjects taking the active medication, compared with those taking the placebo on days 3 and 7. In addition, the medication was well tolerated.
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Authors | R A Hyndiuk, E M Burd, A Hartz |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 34
Issue 4
Pg. 610-3
(Apr 1990)
ISSN: 0066-4804 [Print] United States |
PMID | 2344168
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Mercury Compounds
- Ointments
- Oxides
- Mercury
- mercuric oxide
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Topics |
- Adult
- Aged
- Blepharitis
(drug therapy, microbiology)
- Colony Count, Microbial
- Double-Blind Method
- Drug Evaluation
- Eye Infections, Bacterial
(drug therapy)
- Eyelid Diseases
(drug therapy)
- Female
- Humans
- Male
- Mercury
(administration & dosage, adverse effects)
- Mercury Compounds
- Middle Aged
- Ointments
- Oxides
(administration & dosage, adverse effects)
- Random Allocation
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