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Efficacy and safety of mercuric oxide in the treatment of bacterial blepharitis.

Abstract
A double-masked, placebo-controlled, randomized study was done to assess the safety and clinical and quantitative microbiologic efficacy of 1% mercuric oxide (yellow) ophthalmic ointment in the treatment of eyelid infections, i.e., bacterial blepharitis. A total of 39 patients with bacterial counts and clinical signs indicative of eyelid infection were treated twice daily for 7 days. Clinical biomicroscopic examination and quantitative microbiologic cultures were done just prior to initiation of treatment and again on days 3 and 7. Statistical analysis revealed a significant improvement in the clinical signs, bacterial count, cure rate, and improvement rate for subjects taking the active medication, compared with those taking the placebo on days 3 and 7. In addition, the medication was well tolerated.
AuthorsR A Hyndiuk, E M Burd, A Hartz
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 34 Issue 4 Pg. 610-3 (Apr 1990) ISSN: 0066-4804 [Print] United States
PMID2344168 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Mercury Compounds
  • Ointments
  • Oxides
  • Mercury
  • mercuric oxide
Topics
  • Adult
  • Aged
  • Blepharitis (drug therapy, microbiology)
  • Colony Count, Microbial
  • Double-Blind Method
  • Drug Evaluation
  • Eye Infections, Bacterial (drug therapy)
  • Eyelid Diseases (drug therapy)
  • Female
  • Humans
  • Male
  • Mercury (administration & dosage, adverse effects)
  • Mercury Compounds
  • Middle Aged
  • Ointments
  • Oxides (administration & dosage, adverse effects)
  • Random Allocation

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