Abstract | PURPOSE: To investigate the feasibility of a three-dimensional amide- proton-transfer ( APT) imaging sequence with gradient- and spin-echo readouts at 3 Tesla in patients with high- or low-grade gliomas. MATERIALS AND METHODS: Fourteen patients with newly diagnosed gliomas were recruited. After B0 inhomogeneity correction on a voxel-by-voxel basis, APT-weighted images were reconstructed using a magnetization-transfer-ratio asymmetry at offsets of ±3.5 ppm with respect to the water resonance. Analysis of variance post hoc tests were used for statistical evaluations, and results were validated with pathology. RESULTS: In six patients with gadolinium-enhancing high-grade gliomas, enhancing tumors on the postcontrast T1 -weighted images were consistently hyperintense on the APT-weighted images. Increased APT-weighted signal intensity was also clearly visible in two pathologically proven, high-grade gliomas without gadolinium enhancement. The average APT-weighted signal was significantly higher in the lesions than in the contralateral normal-appearing brain tissue (P < 0.001). In six low-grade gliomas, including two with gadolinium enhancement, APT-weighted imaging showed iso-intensity or mild punctate hyperintensity within all the lesions, which was significantly lower than that seen in the high-grade gliomas (P < 0.001). CONCLUSION: The proposed three-dimensional APT imaging sequence can be incorporated into standard brain MRI protocols for patients with malignant gliomas.
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Authors | Jinyuan Zhou, He Zhu, Michael Lim, Lindsay Blair, Alfredo Quinones-Hinojosa, Steven A Messina, Charles G Eberhart, Martin G Pomper, John Laterra, Peter B Barker, Peter C M van Zijl, Jaishri O Blakeley |
Journal | Journal of magnetic resonance imaging : JMRI
(J Magn Reson Imaging)
Vol. 38
Issue 5
Pg. 1119-28
(Nov 2013)
ISSN: 1522-2586 [Electronic] United States |
PMID | 23440878
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Wiley Periodicals, Inc. |
Chemical References |
- Amides
- Protons
- Gadolinium
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Topics |
- Adult
- Aged
- Algorithms
- Amides
- Brain Neoplasms
(pathology)
- Feasibility Studies
- Female
- Gadolinium
- Glioma
(pathology)
- Humans
- Image Enhancement
(methods)
- Image Interpretation, Computer-Assisted
(methods)
- Imaging, Three-Dimensional
(methods)
- Magnetic Resonance Imaging
(methods)
- Male
- Middle Aged
- Pilot Projects
- Protons
- Reproducibility of Results
- Sensitivity and Specificity
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