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Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement.

AbstractPURPOSE:
To investigate the feasibility of a three-dimensional amide-proton-transfer (APT) imaging sequence with gradient- and spin-echo readouts at 3 Tesla in patients with high- or low-grade gliomas.
MATERIALS AND METHODS:
Fourteen patients with newly diagnosed gliomas were recruited. After B0 inhomogeneity correction on a voxel-by-voxel basis, APT-weighted images were reconstructed using a magnetization-transfer-ratio asymmetry at offsets of ±3.5 ppm with respect to the water resonance. Analysis of variance post hoc tests were used for statistical evaluations, and results were validated with pathology.
RESULTS:
In six patients with gadolinium-enhancing high-grade gliomas, enhancing tumors on the postcontrast T1 -weighted images were consistently hyperintense on the APT-weighted images. Increased APT-weighted signal intensity was also clearly visible in two pathologically proven, high-grade gliomas without gadolinium enhancement. The average APT-weighted signal was significantly higher in the lesions than in the contralateral normal-appearing brain tissue (P < 0.001). In six low-grade gliomas, including two with gadolinium enhancement, APT-weighted imaging showed iso-intensity or mild punctate hyperintensity within all the lesions, which was significantly lower than that seen in the high-grade gliomas (P < 0.001).
CONCLUSION:
The proposed three-dimensional APT imaging sequence can be incorporated into standard brain MRI protocols for patients with malignant gliomas.
AuthorsJinyuan Zhou, He Zhu, Michael Lim, Lindsay Blair, Alfredo Quinones-Hinojosa, Steven A Messina, Charles G Eberhart, Martin G Pomper, John Laterra, Peter B Barker, Peter C M van Zijl, Jaishri O Blakeley
JournalJournal of magnetic resonance imaging : JMRI (J Magn Reson Imaging) Vol. 38 Issue 5 Pg. 1119-28 (Nov 2013) ISSN: 1522-2586 [Electronic] United States
PMID23440878 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Wiley Periodicals, Inc.
Chemical References
  • Amides
  • Protons
  • Gadolinium
Topics
  • Adult
  • Aged
  • Algorithms
  • Amides
  • Brain Neoplasms (pathology)
  • Feasibility Studies
  • Female
  • Gadolinium
  • Glioma (pathology)
  • Humans
  • Image Enhancement (methods)
  • Image Interpretation, Computer-Assisted (methods)
  • Imaging, Three-Dimensional (methods)
  • Magnetic Resonance Imaging (methods)
  • Male
  • Middle Aged
  • Pilot Projects
  • Protons
  • Reproducibility of Results
  • Sensitivity and Specificity

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