Abstract | OBJECTIVES: METHODS: We retrospectively reviewed 143 patients in whom preoperative serum I- CTP level was measured from January 2006 to March 2011, including 91 males and 52 females with an average age of 70.1 ± 8.2 years. Histological subtypes included adenocarcinoma (n = 95), squamous cell carcinoma (n = 34) and other (n = 14). Preoperative serum carcinoembryonic antigen (CEA) and cytokeratin-19 fragment (CYFRA) levels were also measured. Patients with abnormal renal function or preoperative bone fractures were excluded. RESULTS: The mean preoperative serum I- CTP level was 4.1 ± 1.6 ng/ml, and the preoperative serum I- CTP level was elevated (>4.5 ng/ml) in 29 patients. Distant metastasis was detected in 21 patients during the 39 ± 18 (range 1-79) months of follow-up. The rate of distant metastasis was significantly higher in patients with elevated preoperative serum I- CTP levels than those with normal preoperative I- CTP levels (≤4.5 ng/ml) (P < 0.0001). The 5-year recurrence-free survival rate was lower in patients with elevated preoperative serum I- CTP levels than those with normal preoperative I- CTP levels (41.8 vs 92.9%; P < 0.0001). CONCLUSIONS: An elevated preoperative serum I- CTP level predicts postoperative distant metastasis in patients with NSCLC.
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Authors | Yumi Tanaka, Tatsuya Yoshimasu, Shoji Oura, Yoshimitsu Hirai, Mitsumasa Kawago, Masako Ikeda, Yoshitaka Okamura |
Journal | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
(Eur J Cardiothorac Surg)
Vol. 44
Issue 3
Pg. 539-43; discussion 543
(Sep 2013)
ISSN: 1873-734X [Electronic] Germany |
PMID | 23435520
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Carcinoembryonic Antigen
- Collagen Type I
- Keratin-19
- Peptides
- collagen type I trimeric cross-linked peptide
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Topics |
- Aged
- Analysis of Variance
- Biomarkers, Tumor
(blood)
- Carcinoembryonic Antigen
(blood)
- Carcinoma, Non-Small-Cell Lung
(blood, pathology)
- Collagen Type I
(blood)
- Female
- Humans
- Kaplan-Meier Estimate
- Keratin-19
(blood)
- Lung Neoplasms
(blood, pathology)
- Male
- Neoplasm Metastasis
- Peptides
(blood)
- ROC Curve
- Retrospective Studies
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