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Preoperative serum pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen level predicts postoperative distant metastasis in patients with non-small-cell lung cancer.

AbstractOBJECTIVES:
To examine the relationship between preoperative serum pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (I-CTP) levels and postoperative distant metastasis in patients with non-small-cell lung cancer (NSCLC).
METHODS:
We retrospectively reviewed 143 patients in whom preoperative serum I-CTP level was measured from January 2006 to March 2011, including 91 males and 52 females with an average age of 70.1 ± 8.2 years. Histological subtypes included adenocarcinoma (n = 95), squamous cell carcinoma (n = 34) and other (n = 14). Preoperative serum carcinoembryonic antigen (CEA) and cytokeratin-19 fragment (CYFRA) levels were also measured. Patients with abnormal renal function or preoperative bone fractures were excluded.
RESULTS:
The mean preoperative serum I-CTP level was 4.1 ± 1.6 ng/ml, and the preoperative serum I-CTP level was elevated (>4.5 ng/ml) in 29 patients. Distant metastasis was detected in 21 patients during the 39 ± 18 (range 1-79) months of follow-up. The rate of distant metastasis was significantly higher in patients with elevated preoperative serum I-CTP levels than those with normal preoperative I-CTP levels (≤4.5 ng/ml) (P < 0.0001). The 5-year recurrence-free survival rate was lower in patients with elevated preoperative serum I-CTP levels than those with normal preoperative I-CTP levels (41.8 vs 92.9%; P < 0.0001).
CONCLUSIONS:
An elevated preoperative serum I-CTP level predicts postoperative distant metastasis in patients with NSCLC.
AuthorsYumi Tanaka, Tatsuya Yoshimasu, Shoji Oura, Yoshimitsu Hirai, Mitsumasa Kawago, Masako Ikeda, Yoshitaka Okamura
JournalEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (Eur J Cardiothorac Surg) Vol. 44 Issue 3 Pg. 539-43; discussion 543 (Sep 2013) ISSN: 1873-734X [Electronic] Germany
PMID23435520 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Carcinoembryonic Antigen
  • Collagen Type I
  • Keratin-19
  • Peptides
  • collagen type I trimeric cross-linked peptide
Topics
  • Aged
  • Analysis of Variance
  • Biomarkers, Tumor (blood)
  • Carcinoembryonic Antigen (blood)
  • Carcinoma, Non-Small-Cell Lung (blood, pathology)
  • Collagen Type I (blood)
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Keratin-19 (blood)
  • Lung Neoplasms (blood, pathology)
  • Male
  • Neoplasm Metastasis
  • Peptides (blood)
  • ROC Curve
  • Retrospective Studies

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