Abstract |
We studied the macular pigment ocular density (MPOD) in patients with early age macular degeneration (AMD) before and 1 year after nutritional supplementation with lutein and docosahexaenoic acid (DHA). Forty-four patients with AMD were randomly divided into two groups that received placebo (n = 21) or a nutritional supplement (n = 23, 12 mg of lutein and 280 mg of DHA daily). Heterochromatic flicker photometry was used to determine the MPOD. At baseline, the MPOD in AMD patients with placebo was 0.286 ± 0.017 meanwhile in AMD patients with supplementation it was 0.291 ± 0.016. One year later, the mean MPOD had increased by 0.059 in the placebo group and by 0.162 in patients receiving lutein and DHA. This difference between groups was significant (p < 0.05). Lutein and DHA supplementation is effective in increasing the MPOD and may aid in prevention of age related macular degeneration.
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Authors | Alfredo García-Layana, Sergio Recalde, Angel Salinas Alamán, Patricia Fernández Robredo |
Journal | Nutrients
(Nutrients)
Vol. 5
Issue 2
Pg. 543-51
(Feb 15 2013)
ISSN: 2072-6643 [Electronic] Switzerland |
PMID | 23434908
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Placebos
- Retinal Pigments
- Docosahexaenoic Acids
- Lutein
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Topics |
- Aged
- Dietary Supplements
- Docosahexaenoic Acids
(administration & dosage)
- Female
- Humans
- Lutein
(administration & dosage)
- Macula Lutea
(pathology, physiopathology)
- Macular Degeneration
(pathology, physiopathology, prevention & control)
- Male
- Photometry
- Placebos
- Retinal Pigments
- Visual Acuity
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