Abstract |
Pulmonary arterial hypertension (PAH) still cannot be cured effectively, hence the search for novel treatments continues. The effects of sildenafil (25 mg/kg body weight) and fasudil (30 mg/kg body weight) given alone or in combination, on normalization of right ventricular pressure (RVP), right ventricle mass, as well as the levels of several biomarkers (HDL-C, BNP, VEGF-A), were assessed in a rat model of monocrotaline (MCT)-induced PAH. MCT (60 mg/kg body weight) induced clear PAH in male Wistar rats. After 21 days, a significant decrease in RVP accompanied by a reduction of right ventricular hypertrophy - a significant decrease in the right ventricle/left ventricle plus septum ratio - as a result of sildenafil or fasudil administration was assessed. The administration of fasudil and sildenafil alone or in combination caused a significant decrease in plasma BNP level as compared to MCT-treated rats. Fasudil alone or with sildenafil, but not sildenafil alone, significantly increased HDL-C level as compared to MCT-treated rats. Fasudil and sildenafil given alone or in combination caused a significant increase in plasma VEGF-A level as compared to rats exposed to MCT.
|
Authors | Magdalena Jasińska-Stroschein, Jacek Owczarek, Anna Łuczak, Daria Orszulak-Michalak |
Journal | Pharmacology
(Pharmacology)
Vol. 91
Issue 3-4
Pg. 178-84
( 2013)
ISSN: 1423-0313 [Electronic] Switzerland |
PMID | 23428587
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2013 S. Karger AG, Basel. |
Chemical References |
- Cholesterol, HDL
- Phosphodiesterase 5 Inhibitors
- Piperazines
- Protein Kinase Inhibitors
- Purines
- Sulfones
- Vascular Endothelial Growth Factor A
- vascular endothelial growth factor A, rat
- Natriuretic Peptide, Brain
- Monocrotaline
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
- Sildenafil Citrate
- rho-Associated Kinases
- fasudil
|
Topics |
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
(administration & dosage, analogs & derivatives)
- Animals
- Cholesterol, HDL
(blood)
- Drug Therapy, Combination
- Familial Primary Pulmonary Hypertension
- Hemodynamics
(drug effects)
- Hypertension, Pulmonary
(blood, chemically induced, drug therapy, physiopathology)
- Male
- Monocrotaline
- Natriuretic Peptide, Brain
(blood)
- Phosphodiesterase 5 Inhibitors
(administration & dosage)
- Piperazines
(administration & dosage)
- Protein Kinase Inhibitors
(administration & dosage)
- Purines
(administration & dosage)
- Rats
- Rats, Wistar
- Sildenafil Citrate
- Sulfones
(administration & dosage)
- Vascular Endothelial Growth Factor A
(blood)
- rho-Associated Kinases
(antagonists & inhibitors)
|