[Dapsone-induced decrease in the HbA(1c) level may cause artefacts in diabetic control].

Abstract

Glycated haemoglobin (HbA(1c)) level is used to monitor glycaemic control in diabetic patients, and has recently been included as a diagnostic factor for type 2 diabetes mellitus (DM). A 50-year-old male with well-controlled type 1 DM, Mb Addison and coeliac disease was diagnosed with dermatitis herpetiformis and treated with dapsone. Subsequently, the patient presented a pronounced drop in HbA(1c) levels without changes in blood glucose levels. S-fructosamine values were in agreement with the previous stable HbA(1c) values. Blood analyses showed inappropriately low HbA(1c) values due to mild haemolysis and shortening of erythrocyte lifetime without anaemia.

• Authors: Siv Elisabeth Lajlev, Søren Andreas Ladefoged, Kjeld Hermansen
• Journal: Ugeskrift for laeger (Ugeskr Laeger) Vol. 175 Issue 8 Pg. 505-6 (Feb 18 2013) ISSN: 1603-6824 [Electronic] Denmark
• Vernacular Title: Dapsoninduceret fald i HbA(1c) kan give et falskt billede af diabeteskontrollen.
• PMID: 23428267 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Infective Agents
• Glycated Hemoglobin A
• hemoglobin A1c protein, human
• Dapsone

Topics

• Anti-Infective Agents (administration & dosage, adverse effects, therapeutic use)
• Dapsone (administration & dosage, adverse effects, therapeutic use)
• Dermatitis Herpetiformis (drug therapy)
• Diabetes Mellitus, Type 1 (blood)
• Glycated Hemoglobin (analysis, drug effects, metabolism)
• Hemolysis (drug effects)
• Humans
• Male
• Middle Aged