Abstract | BACKGROUND: METHODS: Data was reviewed from untreated CLL patients in the national Israel CLL database, followed during 1987 to 2012. All bone marrow biopsies were graded for reticulin fibrosis using a modified scoring system containing 4 grades (0-3), based on the European consensus report. Grade of reticulin fibrosis was correlated with overall survival (OS), outcome, and a number of well-recognized prognostic factors for CLL. RESULTS: The final cohort included 176 patients (122 males and 51 females). Median age was 63 years (range, 32-86 years) and the 5-year OS was 77.1%. Grade of BM reticulin fibrosis correlated with OS (P < .0001) and mortality (P = .001), and separated patients into 2 groups with different survival curves. Advanced reticulin fibrosis (grades 2-3) was associated with thrombocytopenia (platelet counts of < 100,000/mm(3) ) (P = .025), anemia (P = .018), elevated β2-microglobulin < 4000 μg/mL (P = .048), and the presence of 11q deletion (P = .0015). CONCLUSIONS: There was a significant correlation between poor survival and grade of BM reticulin fibrosis. This staining procedure is easy to perform and can readily be added routinely when examining BM biopsies in CLL, because the findings do have prognostic implications.
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Authors | Tamar Tadmor, Lev Shvidel, Ariel Aviv, Rosa Ruchlemer, Osnat Bairey, Mona Yuklea, Yair Herishanu, Andre Braester, Naomi Rahimi-Levene, Naomi Levene, Fiona Vernea, Jonathan Ben-Ezra, Jacob Bejar, Aaron Polliack, Israeli CLL Study Group |
Journal | Cancer
(Cancer)
Vol. 119
Issue 10
Pg. 1853-9
(May 15 2013)
ISSN: 1097-0142 [Electronic] United States |
PMID | 23423815
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 American Cancer Society. |
Chemical References |
- Coloring Agents
- Reticulin
- beta 2-Microglobulin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anemia
(blood, complications)
- Bone Marrow
(chemistry, pathology)
- Bone Marrow Examination
- Chromosomes, Human, Pair 11
- Coloring Agents
- Female
- Gene Deletion
- Humans
- Israel
(epidemiology)
- Kaplan-Meier Estimate
- Leukemia, Lymphocytic, Chronic, B-Cell
(complications, mortality, pathology)
- Leukocyte Count
- Male
- Middle Aged
- Neoplasm Staging
- Odds Ratio
- Platelet Count
- Predictive Value of Tests
- Primary Myelofibrosis
(diagnosis)
- Prognosis
- Proportional Hazards Models
- Reticulin
- Retrospective Studies
- Severity of Illness Index
- Silver Staining
(methods)
- Thrombocytopenia
(blood, complications)
- beta 2-Microglobulin
(blood)
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